Compare Phenergan vs. Sancuso

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Phenergan (Promethazine)

Prescription only

Sancuso (granisetron)

Prescription only
Helps you feel less queasy.

Phenergan (Promethazine) is used to treat and prevent nausea and vomiting from surgery, motion sickness, or pregnancy. While it's cheap and available in different forms to make it easier to take, it can make you feel very sleepy, and its side effects mean that children under 2 and adults over 65 shouldn't take it.

4.4/ 5 average rating with 38 reviewsforPhenergan
Helps reduce nausea and vomiting.

Sancuso (granisetron) is a good choice to reduce nausea and vomiting if it's hard for you to take oral medicines, but is very expensive.

Upsides
  • Available in generic.
  • Available as a syrup or tablet that you can take by mouth, or as a rectal suppository if you're unable to take anything by mouth.
  • Each Sancuso (granisetron) patch provides around-the-clock relief from nausea and vomiting for up to 7 days without having to re-dose and without problems associated with missing a dose.
  • May be a better option for some people on multi-day chemotherapy regimens.
Downsides
  • Can make you feel very sleepy, especially if you're taking other drugs that can make you sleepy or if you drink alcohol.
  • Can't be used in children under 2 years of age or if you're over 65 because of increased risk from side effects.
  • Can make your skin more sensitive to the sun.
  • Must be applied at least 24 hours before the scheduled chemotherapy.
  • Sancuso (granisetron) has the possibility of interacting with antidepressants that can result in a dangerous build up of serotonin.
  • Must restrict from certain activites such as swimming and strenous excerise while wearing Sancuso (granisetron).
  • Should be used with caution in people with any heart condition.
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Used for
Dosage forms
  • Pill
  • Liquid
  • Suppository
  • Patch
Price
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Reviews
38 reviews so far
82%
saidit'sworth it
76%
saiditworked well
5%
saidit'sa big hassle

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Side effects
The Phenergan (Promethazine) FDA package insert doesn’t have numbers about how common side effects are.
The Sancuso (granisetron) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Slowing or stopping of breathing
    • Children under 2 years of age
  • Seizures
    • History of seizures
  • Sunburn
  • Involuntary muscle movements
    • Age over 65
  • Neuroleptic malignant syndrome
See more detailed risks and warnings
  • Rare serious drug interaction
    • Taking other medicines that affect serotonin levels such as tramadol and anti-depressants
  • Heart disease
  • Masking of intestinal blockage and stomach bloating
  • Skin reactions
  • Heat exposure
    • Exposure to heat
  • Sun exposure
    • Exposure to sun
See more detailed risks and warnings