Compare pilocarpine vs. Combigan

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Lowers eye pressure and constricts the pupil.

Isopto Carpine (pilocarpine) is a very effective first choice medicine for treating high eye pressure to prevent the onset or worsening of glaucoma, but you may have to use up to 4 times daily.

An eyedrop used to treat increased pressure inside the eye

An effective control of high pressure within the eye when used alone or with other eye medications. Lowering eye pressure back to normal can prevent the onset of glaucoma.

Upsides
  • It takes about 1 hour for Isopto Carpine (pilocarpine) to lower dangerously high eye pressure.
  • It does not require dose adjustments in patients with liver or kidney problems.
  • Available as a generic.
  • The two medicines do not have to be taken separately
Downsides
  • Isopto Carpine (pilocarpine) causes the pupil of the eye to become smaller, which results in dim vision, particularly at night.
  • Alternatives are easier to use than this medication, since it requires more drops throughout the day.
  • Isopto Carpine (pilocarpine) is a recommended choice, but it may not work for more serious conditions.
  • The medicine is absorbed into your body and therefore may react to other conditions you have, such as heart or lung conditions
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Used for
  • Glaucoma
  • In patients requiring adjunctive or replacement therapy Ocular hypertension
  • In patients requiring adjunctive or replacement therapy
Dosage forms
  • Eye drops
  • Eye drops
Price
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Reviews
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Side effects
The Isopto Carpine (pilocarpine) FDA package insert doesn’t have numbers about how common side effects are.
The Combigan (Brimonidine / Timolol) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Reduced visual acuity
  • Retinal disease
    • Retinal disease
  • Increased intraocular pressure in children
    • Use of Isopto Carpine (pilocarpine) in pediatric patients
See more detailed risks and warnings
  • Heart problems (Cardiovascular Risk)
    • High blood Pressure
    • irregular heart beats
  • Lung conditions
    • People with Asthma, COPD, or other breathing conditions
  • Redness in eye
    • Long term use
  • Visual Changes
  • Young children
See more detailed risks and warnings