Compare Prandimet vs. glyburide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lowers blood sugar.

Prandimet (metformin / repaglinide) effectively controls blood sugar levels for patients who are not controlled on either metformin or repaglinide alone.

Lowers blood sugar.

Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.

3.3/ 5 average rating with 110 reviewsforglyburide
  • Prandimet (metformin / repaglinide) combines 2 medications into one pill, which makes it easier to take.
  • Prandimet (metformin / repaglinide) is fast-acting and reaches full effect within an hour.
  • Available as an oral tablet.
  • Lowers your A1c (average blood sugar over time) up to 2%.
  • Available in generic version.
  • Available in single pill combination with other anti-diabetic medicines.
  • Prandimet (metformin / repaglinide) should not be used in those with liver or kidney problems.
  • Has to be taken with meals.
  • Should not be used in children under 18 years old.
  • May cause weight gain and low blood sugar.
  • More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
  • You will have to check your blood sugar often when you first start taking it.
  • Can cause weight gain (about 2 to 3 pounds).
  • Not ideal for elderly or those with poor kidney function.
  • May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
Used for
Dosage forms
  • Pill
  • Pill
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Side effects
6possible side effects
  • Digestive problems
  • Low blood sugar
  • Headache
  • Diarrhea
  • Nausea
  • Common cold
See more detailed side effects
2possible side effects
  • Nausea and heartburn
  • Skin allergies
See more detailed side effects
Risks and risk factors
  • Excess lactic acid
    • Kidney problems
    • Liver problems
    • Congestive heart failure
    • Using contrast dye for procedures
    • Surgery
    • Alcohol use
  • Low blood sugar (hypoglycemia)
    • Alcoholism
    • Changes in meal pattern
    • Changes in exercise
    • Insulin
    • Other antidiabetic medications
  • Interactions with other drugs
    • Taking certain medications that increase the amount of Prandimet (metformin / repaglinide)
  • Heart damage
    • Using Novolin or Humulin
  • Low vitamin B12 levels
See more detailed risks and warnings
  • Low blood sugar
    • Over age 65
    • Kidney problems
    • Use of other blood sugar lowering medicines
    • Alcohol
    • Intense physical activity
  • Severe allergic reactions
    • History of sulfa allergies
See more detailed risks and warnings