Compare Prandimet vs. Glyset

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lowers blood sugar.

Prandimet (metformin / repaglinide) effectively controls blood sugar levels for patients who are not controlled on either metformin or repaglinide alone.

Lowers blood sugar.

Glyset (miglitol) controls your blood sugar, but the side effects and how you're supposed to take it can make it hard to take every day.

  • Prandimet (metformin / repaglinide) combines 2 medications into one pill, which makes it easier to take.
  • Prandimet (metformin / repaglinide) is fast-acting and reaches full effect within an hour.
  • Glyset (miglitol) controls post-meal time blood sugars and does not cause weight gain.
  • Glyset (miglitol) doesn't cause low blood sugar as much as other similar medications.
  • Safe for people 65 years and older.
  • Glyset (miglitol) won't increase your risk of bone fractures like some other antidiabetic drugs.
  • Prandimet (metformin / repaglinide) should not be used in those with liver or kidney problems.
  • Has to be taken with meals.
  • Should not be used in children under 18 years old.
  • May cause weight gain and low blood sugar.
  • Glyset (miglitol) isn't a first choice medication because it doesn't lower blood sugar as well as others.
  • You have to take Glyset (miglitol) 3 times a day with each meal.
  • Glyset (miglitol) can cause diarrhea, excessive gas, and stomach pain when you first start taking it.
  • Not recommended for children under 18.
Used for
Dosage forms
  • Pill
  • Pill
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Side effects
6possible side effects
  • Digestive problems
  • Low blood sugar
  • Headache
  • Diarrhea
  • Nausea
  • Common cold
See more detailed side effects
The Glyset (miglitol) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Excess lactic acid
    • Kidney problems
    • Liver problems
    • Congestive heart failure
    • Using contrast dye for procedures
    • Surgery
    • Alcohol use
  • Low blood sugar (hypoglycemia)
    • Alcoholism
    • Changes in meal pattern
    • Changes in exercise
    • Insulin
    • Other antidiabetic medications
  • Interactions with other drugs
    • Taking certain medications that increase the amount of Prandimet (metformin / repaglinide)
  • Heart damage
    • Using Novolin or Humulin
  • Low vitamin B12 levels
See more detailed risks and warnings
  • Severely low blood sugar (hypoglycemia)
    • Use of other blood sugar-lowering medications
    • Unstable kidney function
  • Kidney problems
    • History of kidney problems
  • Stomach and intestine problems
    • Inflammatory bowel disease
    • Ulcers
    • Bowel obstruction or blockage
    • Trouble absorbing or digesting food
See more detailed risks and warnings