Compare Prandimet vs. metformin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Lowers blood sugar.

Prandimet (metformin / repaglinide) effectively controls blood sugar levels for patients who are not controlled on either metformin or repaglinide alone.

Lowers blood sugar.

Glucophage (metformin) is the first choice medicine to control your blood sugar and lower the risk of death from diabetes, although a few people may not tolerate the stomach side effects.

3.7/ 5 average rating with 938 reviewsformetformin
Upsides
  • Prandimet (metformin / repaglinide) combines 2 medications into one pill, which makes it easier to take.
  • Prandimet (metformin / repaglinide) is fast-acting and reaches full effect within an hour.
  • Improves sugar control and lowers A1c levels as much as 2%.
  • One of the few diabetes medicines that lowers the risk of death from diabetes-related complications.
  • Doesn't cause weight gain.
  • Rarely causes low blood sugar.
Downsides
  • Prandimet (metformin / repaglinide) should not be used in those with liver or kidney problems.
  • Has to be taken with meals.
  • Should not be used in children under 18 years old.
  • May cause weight gain and low blood sugar.
  • Often causes stomach upset, like diarrhea, nausea, gas, or stomach cramping.
  • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
  • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
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Used for
Dosage forms
  • Pill
  • Pill
  • Extended release pill
  • Liquid
Price
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Reviews
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938 reviews so far
65%
saidit'sworth it
46%
saiditworked well
16%
saidit'sa big hassle

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Side effects
6possible side effects
  • Digestive problems
    33%
  • Low blood sugar
    33%
  • Headache
    22%
  • Diarrhea
    19%
  • Nausea
    15%
  • Common cold
    11%
See more detailed side effects
7possible side effects
  • Diarrhea
    53%
  • Nausea/vomiting
    26%
  • Gas
    12%
  • Weakness
    9%
  • Indigestion
    7%
  • Stomach pain
    6%
  • Headache
    6%
See more detailed side effects
Risks and risk factors
  • Excess lactic acid
    • Kidney problems
    • Liver problems
    • Congestive heart failure
    • Using contrast dye for procedures
    • Surgery
    • Alcohol use
  • Low blood sugar (hypoglycemia)
    • Alcoholism
    • Changes in meal pattern
    • Changes in exercise
    • Insulin
    • Other antidiabetic medications
  • Interactions with other drugs
    • Taking certain medications that increase the amount of Prandimet (metformin / repaglinide)
  • Heart damage
    • Using Novolin or Humulin
  • Low vitamin B12 levels
See more detailed risks and warnings
  • Excess lactic acid in the blood
    • Kidney problems
    • Liver problems
    • Congestive heart failure
    • Using contrast dye for procedures
    • Surgery
    • Alcohol use
  • Low vitamin B12 levels
See more detailed risks and warnings