Compare pravastatin vs. simvastatin
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Lowers cholesterol.
Pravachol (pravastatin) can improve cholesterol, but it's not as strong as other statin medicines. It does cause fewer side effects and is safer for your kidneys and liver.
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3.5/ 5 average rating with 426 reviewsforpravastatin
Lowers cholesterol.
Zocor (simvastatin) is a good medication to improve your cholesterol.
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3.8/ 5 average rating with 1176 reviewsforsimvastatin
Upsides
- Compared to other statins, Pravachol (pravastatin) has fewer interactions with medicines.
- Pravachol (pravastatin) is less likely to cause muscle and kidney damage than other statin medicines.
- If you have liver problems, Pravachol (pravastatin) is the safest statin to use.
- It's available as a generic.
- Can lower the risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking.
- Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
- Available in generic.
- Available in combination pills with other cholesterol medicines.
Downsides
- Pravachol (pravastatin) isn't as strong as other statins in lowering your cholesterol.
- You'll still need to eat a low fat diet and exercise regularly to get the full benefit of Pravachol (pravastatin).
- You are at higher risk for side effects if you are female, are 65 years or older, drink alcohol every day, or have liver disease, kidney disease, or diabetes.
- Not safe to use if you're pregnant.
- Can have more drug interactions than some other drugs in the same class (statins).
Used for
- High cholesterol
- High triglycerides
- Heart attack and stroke prevention
Dosage forms
- Pill
- Pill
Price
Lowest price
$177.07
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$248.66
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Reviews
426 reviews so far
54%
saidit'sworth it
44%
saiditworked well
19%
saidit'sa big hassle
Have you used Pravachol (pravastatin)?
Leave a review1176 reviews so far
61%
saidit'sworth it
48%
saiditworked well
14%
saidit'sa big hassle
Have you used Zocor (simvastatin)?
Leave a reviewSide effects
20possible side effects
- Muscle, joint or ligament/tendon pain10%
- Nausea, vomiting7%
- Diarrhea7%
- Headache6%
- Upper respiratory infection6%
- Chest pain5%
- Rash5%
- Dizziness4%
- Stuffy nose4%
- Muscle damage4%
- Flatulence3%
- Indigestion, heartburn3%
- Fatigue3%
- Cough3%
- Increased liver enzymes3%
- Abdominal swelling2%
- Influenza2%
- Muscle pain2%
- Sore throat2%
- Bile duct disease2%
14possible side effects
- Bronchitis7%
- Abdominal pain6%
- Atrial fibrillation6%
- Stomach problems5%
- Balance problems5%
- Eczema5%
- Diabetes4%
- Muscle pain4%
- Insomnia4%
- Edema/swelling3%
- Headache3%
- Infection, urinary tract3%
- Constipation2%
- Sinus infection2%
Risks and risk factors
- Muscle damage
- Kidney disease
- An underactive thyroid
- Over age 65
- Female gender
- Taking other medicines to lower your cholesterol
- Liver damage
- Heavy alcohol use
- History of chronic liver disease
- Harm to fetus
- Pregnancy
- Breast feeding
- Endocrine function
- Spironolactone use
- Cimetidine use
- Ketoconazole use
- Muscle pain and kidney damage
- Kidney disease
- High dose of Zocor (simvastatin)
- Combining Zocor (simvastatin) with other cholesterol-lowering drugs
- Older age
- Female gender
- Liver damage
- Heavy alcohol use
- History of chronic liver disease
- Harm to unborn baby
- Pregnancy
- Breast feeding
- Drug interactions
- Certain drugs can increase the dose of Zocor (simvastatin) in the body
- High blood sugar
- History of high blood sugar