Compare pravastatin vs. Zetia

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Pravachol (pravastatin)

Prescription only

Zetia (ezetimibe)

Prescription only
Lowers cholesterol.

Pravachol (pravastatin) can improve cholesterol, but it's not as strong as other statin medicines. It does cause fewer side effects and is safer for your kidneys and liver.

3.5/ 5 average rating with 426 reviewsforpravastatin
Lowers cholesterol.

Zetia (ezetimibe) can improve your cholesterol and can be used as an alternative to statins.

3.3/ 5 average rating with 128 reviewsforZetia
Upsides
  • Compared to other statins, Pravachol (pravastatin) has fewer interactions with medicines.
  • Pravachol (pravastatin) is less likely to cause muscle and kidney damage than other statin medicines.
  • If you have liver problems, Pravachol (pravastatin) is the safest statin to use.
  • It's available as a generic.
  • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Can be used with other medicines to improve cholesterol.
  • Available in a combination pill with simvastatin.
  • Available as a generic.
Downsides
  • Pravachol (pravastatin) isn't as strong as other statins in lowering your cholesterol.
  • You'll still need to eat a low fat diet and exercise regularly to get the full benefit of Pravachol (pravastatin).
  • Doesn't lower triglycerides (fats).
  • Hasn't been shown to lower the risk of heart attacks or heart disease.
  • By itself, it isn't as effective as statins for improving cholesterol.
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Used for
Dosage forms
  • Pill
  • Pill
Price
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Reviews
426 reviews so far
54%
saidit'sworth it
44%
saiditworked well
19%
saidit'sa big hassle

Have you used Pravachol (pravastatin)?

Leave a review
128 reviews so far
42%
saidit'sworth it
34%
saiditworked well
21%
saidit'sa big hassle

Have you used Zetia (ezetimibe)?

Leave a review
Side effects
20possible side effects
  • Muscle, joint or ligament/tendon pain    
    10%
  • Nausea, vomiting    
    7%
  • Diarrhea    
    7%
  • Headache    
    6%
  • Upper respiratory infection    
    6%
  • Chest pain    
    5%
  • Rash
    5%
  • Dizziness
    4%
  • Stuffy nose
    4%
  • Muscle damage
    4%
  • Flatulence    
    3%
  • Indigestion, heartburn    
    3%
  • Fatigue    
    3%
  • Cough
    3%
  • Increased liver enzymes
    3%
  • Abdominal swelling
    2%
  • Influenza
    2%
  • Muscle pain
    2%
  • Sore throat
    2%
  • Bile duct disease
    2%
See more detailed side effects
12possible side effects
  • Diarrhea
    4%
  • Common cold
    4%
  • Sore throat
    4%
  • Sinus infection
    3%
  • Joint pain
    3%
  • Pain in arms and legs
    3%
  • Muscle pain
    3%
  • Abnormal liver tests
    3%
  • Fatigue
    2%
  • Flu
    2%
  • Back pain
    2%
  • Gallbladder removal
    2%
See more detailed side effects
Risks and risk factors
  • Muscle damage
    • Kidney disease
    • An underactive thyroid
    • Over age 65
    • Female gender
    • Taking other medicines to lower your cholesterol
  • Liver damage
    • Heavy alcohol use
    • History of chronic liver disease
  • Harm to fetus
    • Pregnancy
    • Breast feeding
  • Endocrine function
    • Spironolactone use
    • Cimetidine use
    • Ketoconazole use
See more detailed risks and warnings
  • Harm to fetus
  • Muscle pain
    • Taking Zetia (ezetimibe) with statins
  • Abnormal liver blood tests
    • Past history of liver disease
    • Taking Zetia (ezetimibe) with statins
See more detailed risks and warnings