Compare prednisone vs. Allopurinol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Deltasone (prednisone)

Prescription only

Zyloprim (allopurinol)

Prescription only
Calms down your immune system.

Deltasone (prednisone) is effective for controlling allergic reactions and conditions involving an overactive immune system. It can quickly make you feel better, but Deltasone (prednisone) can cause serious complications and side effects if taken for a long time.

3.5/ 5 average rating with 540 reviewsforprednisone
Lowers uric acid levels in blood, and prevents gout flare-ups.

Zyloprim (allopurinol) works well to prevent gout attacks and is cheaper than some alternatives, but it takes a few weeks to start working.

3.7/ 5 average rating with 21 reviewsforAllopurinol
Upsides
  • Deltasone (prednisone) effectively treats a variety of conditions involving the immune system.
  • Can help improve energy and stimulate your appetite.
  • Works quickly to provide relief for swelling, rash, asthma attacks, and pain.
  • Good long-term treatment option for autoimmune disorders.
  • Deltasone (prednisone) is available in a generic form.
  • Zyloprim (allopurinol) works well to lower uric acid in the body.
  • It is available as a generic medication.
Downsides
  • Deltasone (prednisone) can cause unwanted side effects such as mood changes, trouble sleeping, and increase in blood pressure as well as blood sugar at higher doses.
  • Long-term use can cause problems to your skin, bones, eyes, and place you at a higher risk for infections.
  • If Deltasone (prednisone) is used for more than 2 weeks, you will need to work with a doctor to taper off the medicine by gradually decreasing the dose.
  • Deltasone (prednisone) can harm an unborn baby, so it's not a good option for pregnant women.
  • Zyloprim (allopurinol) can raise the number of gout attacks in the first few weeks.
  • It can take 2 to 6 weeks to feel the full effects of Zyloprim (allopurinol).
  • Kidney stones can form while taking Zyloprim (allopurinol), so you need to drink a lot of fluids to help prevent this.
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Used for
Dosage forms
  • Pill
  • Delayed release pill
  • Liquid
  • Pill
  • Injection
Price
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Reviews
540 reviews so far
59%
saidit'sworth it
45%
saiditworked well
20%
saidit'sa big hassle

Have you used Deltasone (prednisone)?

Leave a review
21 reviews so far
71%
saidit'sworth it
52%
saiditworked well
5%
saidit'sa big hassle

Have you used Zyloprim (allopurinol)?

Leave a review
Side effects
The Deltasone (prednisone) FDA package insert doesn’t have numbers about how common side effects are.
The Zyloprim (allopurinol) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Physicial Dependence
    • Taking high doses of Deltasone (prednisone) for a long period of time
    • Young children
    • Stress such as trauma, injury, or infection
  • Increased risk for infections
    • Taking other medicines that weaken the immune system
    • Taking Deltasone (prednisone) for a long time
    • Those who are not vaccinated against viral illnesses
    • Coming into contact with people who have viral illness
    • History of bacterial or viral conditions
  • Eye problems
    • Those with cataracts and/or glaucoma
    • History of herpes simplex in the eye
  • Changes in heart and kidney function
    • Those who had a recent heart attack
    • History of heart failure, high blood pressure, and kidney problems
  • Effects on bone
    • Taking Deltasone (prednisone) at high doses and/or for a long period of time
    • Infants and young children
    • Age 60 or older
  • Stomach problems
    • History of stomach bleeding
    • History of stomach ulcers
    • History of Ulcerative Colitis
    • Taking Deltasone (prednisone) with other medicines that can also cause stomach problems
See more detailed risks and warnings
  • More gout attacks
  • Kidney stones
    • History of kidney stones
  • Skin rash
  • Liver disease
  • Sleepiness or dizziness
    • Taking other medications that also cause sleepiness
    • Recreational drug use
    • Excessive alcohol use
    • Elderly
See more detailed risks and warnings