Compare prednisone vs. Enbrel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Deltasone (prednisone)

Prescription only

Enbrel (etanercept)

Prescription only
Calms down your immune system.

Deltasone (prednisone) is effective for controlling allergic reactions and conditions involving an overactive immune system. It can quickly make you feel better, but Deltasone (prednisone) can cause serious complications and side effects if taken for a long time.

3.5/ 5 average rating with 540 reviewsforprednisone
Calms down your immune system to prevent joint damage.

Enbrel (etanercept) effectively calms down your immune system, but it puts you at risk of serious infections.

3.7/ 5 average rating with 90 reviewsforEnbrel
Upsides
  • Deltasone (prednisone) effectively treats a variety of conditions involving the immune system.
  • Can help improve energy and stimulate your appetite.
  • Works quickly to provide relief for swelling, rash, asthma attacks, and pain.
  • Good long-term treatment option for autoimmune disorders.
  • Deltasone (prednisone) is available in a generic form.
  • People taking Enbrel (etanercept) for rheumatoid arthritis showed significant improvement and were able to reduce the dose or stop their other RA medicines.
  • Enbrel (etanercept) can work for you even if other medications didn't help your rheumatoid arthritis.
  • Enbrel (etanercept) is the first biologic approved for moderate to severe rheumatoid arthritis. Since it has been around for a long time, its side effects are well known.
  • Many people have only minor or no side effects.
  • It's available as a pre-filled syringe and SureClick auto-injector pen which some people find more convenient and easier to use.
Downsides
  • Deltasone (prednisone) can cause unwanted side effects such as mood changes, trouble sleeping, and increase in blood pressure as well as blood sugar at higher doses.
  • Long-term use can cause problems to your skin, bones, eyes, and place you at a higher risk for infections.
  • If Deltasone (prednisone) is used for more than 2 weeks, you will need to work with a doctor to taper off the medicine by gradually decreasing the dose.
  • Deltasone (prednisone) can harm an unborn baby, so it's not a good option for pregnant women.
  • Enbrel (etanercept) raises your risk of serious or life-threatening infections, including tuberculosis (TB).
  • Enbrel (etanercept) can increase the risk of lymphoma, leukemia and other cancers.
  • May not be the best choice if you have a history of heart failure or nervous system problems like multiple sclerosis.
  • You'll need to have regular blood tests before and during treatment to make sure you don't have any problems taking Enbrel (etanercept).
  • You could get injection site reactions such as redness, swelling, rash, itching, or bruising.
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Used for
Dosage forms
  • Pill
  • Delayed release pill
  • Liquid
  • Injection
Price
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Reviews
540 reviews so far
59%
saidit'sworth it
45%
saiditworked well
20%
saidit'sa big hassle

Have you used Deltasone (prednisone)?

Leave a review
90 reviews so far
62%
saidit'sworth it
53%
saiditworked well
17%
saidit'sa big hassle

Have you used Enbrel (etanercept)?

Leave a review
Side effects
The Deltasone (prednisone) FDA package insert doesn’t have numbers about how common side effects are.
5possible side effects
  • Any infection
    27%
  • Upper respiratory infections
    17%
  • Injection site reactions
    15%
  • Non-upper respiratory infections
    12%
  • Diarrhea
    3%
See more detailed side effects
Risks and risk factors
  • Physicial Dependence
    • Taking high doses of Deltasone (prednisone) for a long period of time
    • Young children
    • Stress such as trauma, injury, or infection
  • Increased risk for infections
    • Taking other medicines that weaken the immune system
    • Taking Deltasone (prednisone) for a long time
    • Those who are not vaccinated against viral illnesses
    • Coming into contact with people who have viral illness
    • History of bacterial or viral conditions
  • Eye problems
    • Those with cataracts and/or glaucoma
    • History of herpes simplex in the eye
  • Changes in heart and kidney function
    • Those who had a recent heart attack
    • History of heart failure, high blood pressure, and kidney problems
  • Effects on bone
    • Taking Deltasone (prednisone) at high doses and/or for a long period of time
    • Infants and young children
    • Age 60 or older
  • Stomach problems
    • History of stomach bleeding
    • History of stomach ulcers
    • History of Ulcerative Colitis
    • Taking Deltasone (prednisone) with other medicines that can also cause stomach problems
See more detailed risks and warnings
  • Serious allergic reactions
    • Latex allergy
  • Heart problems
    • History of heart failure
  • Serious infections
    • Taking other immunosuppressant drugs
    • Age 65 or older
  • Cancer
    • Taking other immunosuppressant drugs
    • History of cancer
  • Nervous system effects
    • History of nervous system conditions
  • Lower blood cell counts
See more detailed risks and warnings