Compare Premarin vaginal cream vs. Alora

Head-to-head comparisons of medication uses, side effects, ratings, and more.

ADVERTISEMENT
Relieves vaginal dryness and pain during sex due to menopause.

Premarin vaginal cream (conjugated estrogens) has less side-effects than estrogen pills, but only works for localized symptoms of menopause.

Relieves hot flashes and vaginal dryness due to menopause and strengthens your bones.

Alora (estradiol patch) treats symptoms from low estrogen, and it may have fewer side effects than oral estrogen pills.

Upsides
  • Works locally in the vagina, so it has less side effects than estrogen pills.
  • Works better than over-the-counter lubricants to relieve pain during sex caused by menopause.
  • Can be dosed twice a week to relieve painful sex due to menopause.
  • Alora (estradiol patch) replaces estrogen to your whole body and relieves many symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • The patch is good for people who don't want to or can't take daily pills.
  • Can be worn while swimming, bathing, and showering.
  • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
  • Lowers your risk of fractures by keeping your bones healthy.
Downsides
  • Vaginal estrogens can weaken latex (rubber) condoms, cervical caps, and diaphragms. Do not rely on these methods to protect against sexually transmitted infections for up to 72 hours after using Premarin vaginal cream (conjugated estrogens).
  • Premarin vaginal cream (conjugated estrogens) increases risk of uterine cancer so women with intact uterus should not use it by itself.
  • Available as a branded product only, so it may be expensive.
  • You need to replace Alora (estradiol patch) twice a week, compared to other patches that are once a week.
  • Patches can fall off.
  • Increases your risk of uterine and breast cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
  • Can't be used in people with liver problems.
ADVERTISEMENT
Used for
  • Vaginal dryness and inflammation due to menopause
  • Painful sex due to menopause
  • Treats hot flashes, night sweats and flushing in women in menopause
  • Treats vaginal changes in women in menopause
  • Treats low estrogen in women
  • Prevents bone thinning in women in menopause
  • Gender confirmation for transgender women
Dosage forms
  • Cream
  • Patch
Price
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Learn more
Reviews
Not enough review data.Leave a review
Not enough review data.Leave a review
Side effects
6possible side effects
  • Pelvic pain
    3%
  • Vaginal discharge
    3%
  • Headache
    2%
  • Breast pain
    2%
  • Vaginal inflammation
    2%
  • Other problems with the vagina or vulva
    2%
See more detailed side effects
31possible side effects
  • Vaginal bleeding
    33%
  • Headache
    21%
  • Lung infection
    16%
  • Pain
    9%
  • Sinus infection
    8%
  • Vaginal inflammation
    8%
  • Breast pain
    7%
  • Back pain
    6%
  • Skin irritation
    6%
  • Accidental injury
    5%
  • Gas
    5%
  • Trouble sleeping
    5%
  • Itchiness
    5%
  • Nausea
    4%
  • Flu like symptoms
    3%
  • Stomach pain
    3%
  • Diarrhea
    3%
  • Depression
    3%
  • Airway inflammation
    3%
  • Cough
    3%
  • Rash
    3%
  • Weakness
    2%
  • Constipation
    2%
  • Swelling of arms and legs
    2%
  • Muscle aches
    2%
  • Anxiety
    2%
  • Sore throat
    2%
  • Breast growth
    2%
  • Bladder infection
    2%
  • White or yellow vaginal discharge
    2%
  • Breast tumor
    2%
See more detailed side effects
Risks and risk factors
  • Endometrial cancer
    • Using estrogen for more than one year
    • Higher dose of estrogen
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen and progestin for more than one year
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Pancreas swelling (pancreatitis)
    • High levels of triglycerides
See more detailed risks and warnings
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen for more than one year
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Pancreas swelling (pancreatitis)
    • High levels of triglycerides
See more detailed risks and warnings