Compare Premarin vaginal cream vs. Elestrin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Relieves vaginal dryness and pain during sex due to menopause.

Premarin vaginal cream (conjugated estrogens) has less side-effects than estrogen pills, but only works for localized symptoms of menopause.

Relieves hot flashes due to menopause.

Elestrin (Estradiol gel) is a good, easy-to-use option if you don’t want to use pills or patches with estrogen hormones.

Upsides
  • Works locally in the vagina, so it has less side effects than estrogen pills.
  • Works better than over-the-counter lubricants to relieve pain during sex caused by menopause.
  • Can be dosed twice a week to relieve painful sex due to menopause.
  • Elestrin (Estradiol gel) replaces estrogen to your whole body and relieves multiple symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • Elestrin (Estradiol gel) is good for people who don't want to or can't take daily pills.
  • Elestrin (Estradiol gel) has fewer side effects than birht control pills since there are lower amounts of estrogen.
  • Most people start to feel better within 3-4 weeks of starting Elestrin (Estradiol gel).
Downsides
  • Vaginal estrogens can weaken latex (rubber) condoms, cervical caps, and diaphragms. Do not rely on these methods to protect against sexually transmitted infections for up to 72 hours after using Premarin vaginal cream (conjugated estrogens).
  • Premarin vaginal cream (conjugated estrogens) increases risk of uterine cancer so women with intact uterus should not use it by itself.
  • Available as a branded product only, so it may be expensive.
  • Taking Elestrin (Estradiol gel) increases your risk for many conditions, like endometrial or breast cancer, dementia, heart disease, and blood clots.
  • You have to use Elestrin (Estradiol gel) with another hormone called progestin to lower your risk of uterine cancer.
  • Not a good option for people with liver problems.
  • It's possible to expose other people to the estrogen before it's absorbed by your skin.
  • Can be expensive since it's only available as a brand name product.
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Used for
  • Vaginal dryness and inflammation due to menopause
  • Painful sex due to menopause
Dosage forms
  • Cream
  • Gel
Price
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Reviews
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Side effects
6possible side effects
  • Pelvic pain
    3%
  • Vaginal discharge
    3%
  • Headache
    2%
  • Breast pain
    2%
  • Vaginal inflammation
    2%
  • Other problems with the vagina or vulva
    2%
See more detailed side effects
4possible side effects
  • Unusual vaginal bleeding
    9%
  • Common cold
    9%
  • Breast pain
    8%
  • Lung infection
    4%
See more detailed side effects
Risks and risk factors
  • Endometrial cancer
    • Using estrogen for more than one year
    • Higher dose of estrogen
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen and progestin for more than one year
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Pancreas swelling (pancreatitis)
    • High levels of triglycerides
See more detailed risks and warnings
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen for more than one year
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Pancreas swelling (pancreatitis)
    • High levels of triglycerides
See more detailed risks and warnings