Compare Premarin vaginal cream vs. Estrace vaginal cream
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Relieves vaginal dryness and pain during sex due to menopause.
Premarin vaginal cream (conjugated estrogens) has less side-effects than estrogen pills, but only works for localized symptoms of menopause.
Relieves vaginal dryness due to menopause.
Estrace vaginal cream (Estradiol vaginal cream) works well to treat menopausal symptoms localized to the vagina.
●●●●●
3.9/ 5 average rating with 15 reviewsforEstrace vaginal cream
Upsides
- Works locally in the vagina, so it has less side effects than estrogen pills.
- Works better than over-the-counter lubricants to relieve pain during sex caused by menopause.
- Can be dosed twice a week to relieve painful sex due to menopause.
- Side-effects are limited compared to estrogen pill since application is localized to the vagina only.
Downsides
- Vaginal estrogens can weaken latex (rubber) condoms, cervical caps, and diaphragms. Do not rely on these methods to protect against sexually transmitted infections for up to 72 hours after using Premarin vaginal cream (conjugated estrogens).
- Premarin vaginal cream (conjugated estrogens) increases risk of uterine cancer so women with intact uterus should not use it by itself.
- Available as a branded product only, so it may be expensive.
- Method of application can be difficult or uncomfortable compared to a pill that is taken by mouth.
- It is not effective for hot flashes.
- The cream is not compatible with certain birth control methods. It can weaken latex (rubber) condoms, cervical caps, and diaphrams so avoid use within 72 hours after a dose.
- The applicator can be source of infection if not kept clean.
- Available as a brand name product only.
Used for
- Vaginal dryness and inflammation due to menopause
- Painful sex due to menopause
- Vaginal dryness and inflammation
Dosage forms
- Cream
- Cream
Price
Lowest price
$175.30
Find instant savings near youLowest price
$139.91
Find instant savings near youWant to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Learn more
Reviews
Not enough review data.Leave a review
15 reviews so far
60%
saidit'sworth it
73%
saiditworked well
47%
saidit'sa big hassle
Have you used Estrace vaginal cream (Estradiol vaginal cream)?
Leave a reviewSide effects
6possible side effects
- Pelvic pain3%
- Vaginal discharge3%
- Headache2%
- Breast pain2%
- Vaginal inflammation2%
- Other problems with the vagina or vulva2%
The Estrace vaginal cream (Estradiol vaginal cream) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
- Endometrial cancer
- Using estrogen for more than one year
- Higher dose of estrogen
- Breast cancer
- Personal or family history of breast cancer
- Using estrogen and progestin for more than one year
- Increased risk of blood clots and stroke
- Personal or family history of blood clots
- Smoking
- Obesity
- Systemic lupus erythematosus (SLE)
- Increased risk of heart disease
- Smoking
- Obesity
- High blood pressure
- High blood sugar
- High cholesterol
- Age 50 or older
- Dementia
- Age 65 or older
- Pancreas swelling (pancreatitis)
- High levels of triglycerides
- Endometrial cancer
- Using estrogen for more than one year
- Breast cancer
- Personal or family history of breast cancer
- Using estrogen for more than one year
- Increased risk of blood clots and stroke
- Personal or family history of blood clots
- Smoking
- Obesity
- Systemic lupus erythematosus (SLE)
- Increased risk of heart disease
- Smoking
- Obesity
- High blood pressure
- High blood sugar
- High cholesterol
- Age 50 or older
- Dementia
- Age 65 or older
- Inflammation of pancreas
- High levels of triglycerides