Compare Premarin vaginal cream vs. Estring

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Relieves vaginal dryness and pain during sex due to menopause.

Premarin vaginal cream (conjugated estrogens) has less side-effects than estrogen pills, but only works for localized symptoms of menopause.

Relieves vaginal dryness due to menopause.

Estring (estradiol vaginal ring) is more convenient than other forms of estrogen therapy since you only have to replace it every 3 months, but it needs to be inserted directly into the vagina.

3.3/ 5 average rating with 56 reviewsforEstring
Upsides
  • Works locally in the vagina, so it has less side effects than estrogen pills.
  • Works better than over-the-counter lubricants to relieve pain during sex caused by menopause.
  • Can be dosed twice a week to relieve painful sex due to menopause.
  • Many women find Estring (estradiol vaginal ring) more comfortable to use and easier to apply than creams or gels.
  • Estring (estradiol vaginal ring) may be more convenient since it is dosed once every 3 months compared to alternatives that need to taken daily or twice weekly.
  • Works directly at the site of application and safer than oral estrogen pills.
Downsides
  • Vaginal estrogens can weaken latex (rubber) condoms, cervical caps, and diaphragms. Do not rely on these methods to protect against sexually transmitted infections for up to 72 hours after using Premarin vaginal cream (conjugated estrogens).
  • Premarin vaginal cream (conjugated estrogens) increases risk of uterine cancer so women with intact uterus should not use it by itself.
  • Available as a branded product only, so it may be expensive.
  • Estring (estradiol vaginal ring) may not be the best option if you have a narrow vagina or frequent vaginal infections.
  • The ring can fall out without you noticing.
  • Estring (estradiol vaginal ring) is only available as brand name, so can be expensive.
  • Estring (estradiol vaginal ring) All estrogen therapies increase your risk for uterine cancer, heart problems, and blood clots.
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Used for
  • Vaginal dryness and inflammation due to menopause
  • Painful sex due to menopause
  • Vaginal dryness and inflammation
Dosage forms
  • Cream
  • Vaginal ring
Price
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Reviews
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56 reviews so far
63%
saidit'sworth it
39%
saiditworked well
18%
saidit'sa big hassle

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Side effects
6possible side effects
  • Pelvic pain
    3%
  • Vaginal discharge
    3%
  • Headache
    2%
  • Breast pain
    2%
  • Vaginal inflammation
    2%
  • Other problems with the vagina or vulva
    2%
See more detailed side effects
20possible side effects
  • Headache
    13%
  • Vaginal discharge
    7%
  • Back pain
    6%
  • Yeast infection
    6%
  • Upper airway infection
    5%
  • Vaginal inflammation
    5%
  • Vaginal discomfort/pain
    5%
  • Arthritis
    4%
  • Trouble sleeping
    4%
  • Stomach pain
    4%
  • Sinus infection
    4%
  • Vaginal bleeding
    4%
  • Bacterial growth in the genitals
    4%
  • Joint pain
    3%
  • Nausea
    3%
  • Flu-like symptoms
    3%
  • Bone pain
    2%
  • Bladder infection
    2%
  • Hot flashes
    2%
  • Stress
    2%
See more detailed side effects
Risks and risk factors
  • Endometrial cancer
    • Using estrogen for more than one year
    • Higher dose of estrogen
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen and progestin for more than one year
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Pancreas swelling (pancreatitis)
    • High levels of triglycerides
See more detailed risks and warnings
  • Uterine cancer
    • Using estrogen for more than one year
    • Higher dose of estrogen
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen and progestin for more than one year
  • Blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Inflammation of pancreas (pancreatitis)
    • High levels of triglycerides
See more detailed risks and warnings