Compare Premarin vaginal cream vs. Femring

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Relieves vaginal dryness and pain during sex due to menopause.

Premarin vaginal cream (conjugated estrogens) has less side-effects than estrogen pills, but only works for localized symptoms of menopause.

Relieves hot flashes and vaginal dryness due to menopause.

Femring (estradiol acetate vaginal ring) is dosed more conveniently than other forms of estrogen therapy (pills, gels, patches, and creams), but needs to be inserted directly into the vagina.

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2.6/ 5 average rating with 31 reviewsforFemring
Upsides
  • Works locally in the vagina, so it has less side effects than estrogen pills.
  • Works better than over-the-counter lubricants to relieve pain during sex caused by menopause.
  • Can be dosed twice a week to relieve painful sex due to menopause.
  • Femring (estradiol acetate vaginal ring) may be more convenient since it is dosed once every 3 months compared to other medications that need to taken daily or twice weekly.
  • Many women find Femring (estradiol acetate vaginal ring) more comfortable to use and easier to apply than creams or gels.
  • Unlike other topical therapies, Femring (estradiol acetate vaginal ring) works to improve both hot flashes and vaginal dryness caused by menopause.
Downsides
  • Vaginal estrogens can weaken latex (rubber) condoms, cervical caps, and diaphragms. Do not rely on these methods to protect against sexually transmitted infections for up to 72 hours after using Premarin vaginal cream (conjugated estrogens).
  • Premarin vaginal cream (conjugated estrogens) increases risk of uterine cancer so women with intact uterus should not use it by itself.
  • Available as a branded product only, so it may be expensive.
  • Use of a vaginal ring might not be the best option if you have a narrow vagina or frequent vaginal infections.
  • The ring can fall out without you noticing.
  • Only available as brand name, so it may be expensive if not covered by insurance.
  • All estrogen therapies increase your risk of uterine cancer, heart problems, and blood clots – especially if you have a history of these conditions.
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Used for
  • Vaginal dryness and inflammation due to menopause
  • Painful sex due to menopause
Dosage forms
  • Cream
  • Vaginal ring
Price
Lowest price
$186.38
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Lowest price
$606.12
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Reviews
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31 reviews so far
39%
saidit'sworth it
16%
saiditworked well
19%
saidit'sa big hassle

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Side effects
6possible side effects
  • Pelvic pain
    3%
  • Vaginal discharge
    3%
  • Headache
    2%
  • Breast pain
    2%
  • Vaginal inflammation
    2%
  • Other problems with the vagina or vulva
    2%
See more detailed side effects
8possible side effects
  • Spotting
    8%
  • Headache
    7%
  • Bloating
    7%
  • Vaginal yeast infection
    6%
  • Breast tenderness
    6%
  • Back pain
    6%
  • Sinus infection
    2%
  • Pain in the uterus
    2%
See more detailed side effects
Risks and risk factors
  • Endometrial cancer
    • Using estrogen for more than one year
    • Higher dose of estrogen
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen and progestin for more than one year
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Pancreas swelling (pancreatitis)
    • High levels of triglycerides
See more detailed risks and warnings
  • Uterine cancer
    • Using estrogen for more than one year
    • Higher dose of estrogen
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen and progestin for more than one year
  • Blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Inflammation of pancreas
    • High levels of triglycerides
See more detailed risks and warnings
Learn more about Premarin vaginal cream (conjugated estrogens)
Learn more about Femring (estradiol acetate vaginal ring)