Compare Premarin vaginal cream vs. Provera

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Relieves vaginal dryness and pain during sex due to menopause.

Premarin vaginal cream (conjugated estrogens) has less side-effects than estrogen pills, but only works for localized symptoms of menopause.

Regulates your menstrual cycle and supplements estrogen treatments for menopause.

Provera (Medroxyprogesterone) works well to regulate your menstrual cycle and stop irregular bleeding. It also protects the uterus from estrogen's harmful effects.

Upsides
  • Works locally in the vagina, so it has less side effects than estrogen pills.
  • Works better than over-the-counter lubricants to relieve pain during sex caused by menopause.
  • Can be dosed twice a week to relieve painful sex due to menopause.
  • Provera (Medroxyprogesterone) can be used to treat multiple hormone problems in women.
  • After menopause, taking estrogen raises your risk of uterine cancer. However, taking progesterone, like in Provera (Medroxyprogesterone), along with estrogen gives you the positive effects of estrogen, but also prevents it from damaging your uterus.
  • Women taking an estrogen/progestin combination medications have a lower risk of uterine cancer.
Downsides
  • Vaginal estrogens can weaken latex (rubber) condoms, cervical caps, and diaphragms. Do not rely on these methods to protect against sexually transmitted infections for up to 72 hours after using Premarin vaginal cream (conjugated estrogens).
  • Premarin vaginal cream (conjugated estrogens) increases risk of uterine cancer so women with intact uterus should not use it by itself.
  • Available as a branded product only, so it may be expensive.
  • You can't take Provera (Medroxyprogesterone) if you've had a hysterectomy (your uterus removed). You also can't take it if you're pregnant or breastfeeding, have unusual vaginal bleeding, or have a history of blood clots, certain kinds of cancer, stroke, heart attack, liver problems, or bleeding problems.
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Used for
  • Vaginal dryness and inflammation due to menopause
  • Painful sex due to menopause
  • Amenorrhea
  • Abnormal uterine bleeding
  • Prevention of uterine cancer in women taking estrogen
  • Endometriosis
  • Premenstrual syndrome
  • Breast cancer
  • Uterine cancer
  • Pelvic congestion syndrome
  • Birth control (male)
  • Hirsutism
  • Loss of appetite
  • Osteoporosis
  • Renal cell carcinoma
Dosage forms
  • Cream
  • Pill
Price
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Reviews
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Side effects
6possible side effects
  • Pelvic pain
    3%
  • Vaginal discharge
    3%
  • Headache
    2%
  • Breast pain
    2%
  • Vaginal inflammation
    2%
  • Other problems with the vagina or vulva
    2%
See more detailed side effects
The Provera (Medroxyprogesterone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Endometrial cancer
    • Using estrogen for more than one year
    • Higher dose of estrogen
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen and progestin for more than one year
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Pancreas swelling (pancreatitis)
    • High levels of triglycerides
See more detailed risks and warnings
  • Breast cancer
    • Personal or family history of breast cancer
  • Ovarian cancer
    • Family history of ovarian cancer
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Hypertension
    • Diabetes
    • High cholesterol
    • Systemic lupus erythematosus (SLE)
  • Depression
    • History of depression
  • Liver problems
    • History of liver problems
  • Harm to fetus
    • Women of childbearing age
See more detailed risks and warnings