Compare Premarin vs. Alora
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis.
Premarin (Conjugated Estrogens) relieves menopausal symptoms and prevents bone loss. It's an oral hormone replacement, so it can have a lot of side effects, and it's important to think through the benefits and potential hassles of this drug before using it.
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3.5/ 5 average rating with 154 reviewsforPremarin
Relieves hot flashes and vaginal dryness due to menopause and strengthens your bones.
Alora (estradiol patch) treats symptoms from low estrogen, and it may have fewer side effects than oral estrogen pills.
Upsides
- Premarin (Conjugated Estrogens) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
- Lowers your risk of fractures by keeping your bones healthy. Make sure you also take enough calcium and Vitamin D.
- Improves mood, energy, and mental alertness for some people.
- Does not expose your partner to estrogen during sexual acitivities like vaginal estrogen creams.
- Can help relieve symptoms of prostate cancer or advanced breast cancer in some people.
- Alora (estradiol patch) replaces estrogen to your whole body and relieves many symptoms due to low estrogen, like hot flashes and vaginal dryness.
- The patch is good for people who don't want to or can't take daily pills.
- Can be worn while swimming, bathing, and showering.
- By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
- Lowers your risk of fractures by keeping your bones healthy.
Downsides
- More potential side effects than estrogen creams since it exposes your whole body to estrogen.
- Increases your risk of uterine and breast cancer.
- If you have your uterus, you have to take Premarin (Conjugated Estrogens) with another hormone called progestin to lower your risk of uterine cancer.
- Increases your risk of developing blood clots and stroke.
- Can't be used in people with liver problems.
- Can be expensive since it's only available as a brand name product.
- You need to replace Alora (estradiol patch) twice a week, compared to other patches that are once a week.
- Patches can fall off.
- Increases your risk of uterine and breast cancer.
- Increases your risk of developing blood clots and stroke.
- Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
- Can't be used in people with liver problems.
Used for
- Hot flashes and night sweats
- Vaginal dryness and inflammation
- Low estrogen
- Primary ovarian failure
- Prevention of postmenopausal osteoporosis
- Metastatic breast cancer
- Advanced prostate cancer
- Gender identity disorder (male-to-female transsexual)
- Turner syndrome
- Treats hot flashes, night sweats and flushing in women in menopause
- Treats vaginal changes in women in menopause
- Treats low estrogen in women
- Prevents bone thinning in women in menopause
- Gender confirmation for transgender women
Dosage forms
- Pill
- Patch
Price
Lowest price
$159.07
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$34.85
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Reviews
154 reviews so far
50%
saidit'sworth it
43%
saiditworked well
11%
saidit'sa big hassle
Have you used Premarin (Conjugated Estrogens)?
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Side effects
28possible side effects
- Headache13%
- Abdominal pain9%
- Breast pain7%
- Nausea5%
- Asthenia4%
- Back pain4%
- Pain4%
- Flatulence4%
- Insomnia4%
- Leukorrhea4%
- Vaginal moniliasis4%
- Leg cramps3%
- Depression3%
- Pruritus3%
- Vaginitis3%
- Pelvic pain2%
- Hypertension2%
- Diarrhea2%
- Dyspepsia2%
- Weight gain2%
- Emotional lability2%
- Hypertonia2%
- Acne2%
- Alopecia2%
- Breast enlargement2%
- Breast neoplasm2%
- Cervix disorder2%
- Vaginal hemorrhage2%
31possible side effects
- Vaginal bleeding33%
- Headache21%
- Lung infection16%
- Pain9%
- Sinus infection8%
- Vaginal inflammation8%
- Breast pain7%
- Back pain6%
- Skin irritation6%
- Accidental injury5%
- Gas5%
- Trouble sleeping5%
- Itchiness5%
- Nausea4%
- Flu like symptoms3%
- Stomach pain3%
- Diarrhea3%
- Depression3%
- Airway inflammation3%
- Cough3%
- Rash3%
- Weakness2%
- Constipation2%
- Swelling of arms and legs2%
- Muscle aches2%
- Anxiety2%
- Sore throat2%
- Breast growth2%
- Bladder infection2%
- White or yellow vaginal discharge2%
- Breast tumor2%
Risks and risk factors
- Endometrial cancer
- Using estrogen for more than one year
- Breast cancer
- Personal or family history of breast cancer
- Duration of use
- Increased risk of blood clots and stroke
- Personal or family history of blood clots
- Obesity
- Systemic lupus erythematosus (SLE)
- Increased risk of heart disease
- Smoking
- Obesity
- High blood pressure
- High blood sugar
- High cholesterol
- Age 50 or older
- Memory loss
- Gallbladder problems
- Serious allergic reaction
- Prior severe allergic reaction to Premarin (Conjugated Estrogens)
- Harm to fetus
- Women of childbearing age
- Pancreas swelling (pancreatitis)
- High levels of triglycerides
- Endometrial cancer
- Using estrogen for more than one year
- Breast cancer
- Personal or family history of breast cancer
- Using estrogen for more than one year
- Increased risk of blood clots and stroke
- Personal or family history of blood clots
- Smoking
- Obesity
- Systemic lupus erythematosus (SLE)
- Increased risk of heart disease
- Smoking
- Obesity
- High blood pressure
- High blood sugar
- High cholesterol
- Age 50 or older
- Dementia
- Age 65 or older
- Pancreas swelling (pancreatitis)
- High levels of triglycerides