Compare Premarin vs. Estring

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis.

Premarin (Conjugated Estrogens) relieves menopausal symptoms and prevents bone loss. It's an oral hormone replacement, so it can have a lot of side effects, and it's important to think through the benefits and potential hassles of this drug before using it.

3.5/ 5 average rating with 154 reviewsforPremarin
Relieves vaginal dryness due to menopause.

Estring (estradiol vaginal ring) is more convenient than other forms of estrogen therapy since you only have to replace it every 3 months, but it needs to be inserted directly into the vagina.

3.3/ 5 average rating with 56 reviewsforEstring
Upsides
  • Premarin (Conjugated Estrogens) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also take enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Does not expose your partner to estrogen during sexual acitivities like vaginal estrogen creams.
  • Can help relieve symptoms of prostate cancer or advanced breast cancer in some people.
  • Many women find Estring (estradiol vaginal ring) more comfortable to use and easier to apply than creams or gels.
  • Estring (estradiol vaginal ring) may be more convenient since it is dosed once every 3 months compared to alternatives that need to taken daily or twice weekly.
  • Works directly at the site of application and safer than oral estrogen pills.
Downsides
  • More potential side effects than estrogen creams since it exposes your whole body to estrogen.
  • Increases your risk of uterine and breast cancer.
  • If you have your uterus, you have to take Premarin (Conjugated Estrogens) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can't be used in people with liver problems.
  • Can be expensive since it's only available as a brand name product.
  • Estring (estradiol vaginal ring) may not be the best option if you have a narrow vagina or frequent vaginal infections.
  • The ring can fall out without you noticing.
  • Estring (estradiol vaginal ring) is only available as brand name, so can be expensive.
  • Estring (estradiol vaginal ring) All estrogen therapies increase your risk for uterine cancer, heart problems, and blood clots.
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Used for
  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
  • Low estrogen
  • Primary ovarian failure
  • Prevention of postmenopausal osteoporosis
  • Metastatic breast cancer
  • Advanced prostate cancer
  • Gender identity disorder (male-to-female transsexual)
  • Turner syndrome
  • Vaginal dryness and inflammation
Dosage forms
  • Pill
  • Vaginal ring
Price
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Reviews
154 reviews so far
50%
saidit'sworth it
43%
saiditworked well
11%
saidit'sa big hassle

Have you used Premarin (Conjugated Estrogens)?

Leave a review
56 reviews so far
63%
saidit'sworth it
39%
saiditworked well
18%
saidit'sa big hassle

Have you used Estring (estradiol vaginal ring)?

Leave a review
Side effects
28possible side effects
  • Headache
    13%
  • Abdominal pain
    9%
  • Breast pain
    7%
  • Nausea
    5%
  • Asthenia
    4%
  • Back pain
    4%
  • Pain
    4%
  • Flatulence
    4%
  • Insomnia
    4%
  • Leukorrhea
    4%
  • Vaginal moniliasis
    4%
  • Leg cramps
    3%
  • Depression
    3%
  • Pruritus
    3%
  • Vaginitis
    3%
  • Pelvic pain
    2%
  • Hypertension
    2%
  • Diarrhea
    2%
  • Dyspepsia
    2%
  • Weight gain
    2%
  • Emotional lability
    2%
  • Hypertonia
    2%
  • Acne
    2%
  • Alopecia
    2%
  • Breast enlargement
    2%
  • Breast neoplasm
    2%
  • Cervix disorder
    2%
  • Vaginal hemorrhage
    2%
See more detailed side effects
20possible side effects
  • Headache
    13%
  • Vaginal discharge
    7%
  • Back pain
    6%
  • Yeast infection
    6%
  • Upper airway infection
    5%
  • Vaginal inflammation
    5%
  • Vaginal discomfort/pain
    5%
  • Arthritis
    4%
  • Trouble sleeping
    4%
  • Stomach pain
    4%
  • Sinus infection
    4%
  • Vaginal bleeding
    4%
  • Bacterial growth in the genitals
    4%
  • Joint pain
    3%
  • Nausea
    3%
  • Flu-like symptoms
    3%
  • Bone pain
    2%
  • Bladder infection
    2%
  • Hot flashes
    2%
  • Stress
    2%
See more detailed side effects
Risks and risk factors
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Duration of use
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Memory loss
  • Gallbladder problems
  • Serious allergic reaction
    • Prior severe allergic reaction to Premarin (Conjugated Estrogens)
  • Harm to fetus
    • Women of childbearing age
  • Pancreas swelling (pancreatitis)
    • High levels of triglycerides
See more detailed risks and warnings
  • Uterine cancer
    • Using estrogen for more than one year
    • Higher dose of estrogen
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen and progestin for more than one year
  • Blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Inflammation of pancreas (pancreatitis)
    • High levels of triglycerides
See more detailed risks and warnings