Compare Prempro vs. Climara
Head-to-head comparisons of medication uses, side effects, ratings, and more.
No information currently available
Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis.
Climara (estradiol patch) is a treatment for low estrogen that is used only once weekly, and it may have fewer side effects than oral estrogen pills.
Upsides
No information currently available
- Climara (estradiol patch) replaces estrogen to your whole body and relieves many symptoms due to low estrogen, like hot flashes and vaginal dryness.
- The patch is good for people who don't want to or can't take daily pills.
- Climara (estradiol patch) is available as a generic product, which lowers the cost.
- By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
- Lowers your risk of fractures by keeping your bones healthy.
Downsides
No information currently available
- The patch can fall off, especially if you like to regularly swim, take baths or use saunas or steamrooms.
- Increases your risk of uterine and breast cancer.
- If you have your uterus, you have to use the Climara (estradiol patch) with another hormone called progestin to lower your risk of uterine cancer.
- Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, underactive thyroid and migraines.
- If you're only having vaginal dryness or inflammation and not hot flashes, it's better to use creams that you can apply to the affected area instead of Climara (estradiol patch).
Used for
- Menopause - Moderate to severe abnormal vasomotor function Menopause - Moderate to severe vaginal atrophy - Moderate to severe vulvar atrophy Postmenopausal osteoporosis
- In women with an intact uterus; Prophylaxis
- Hot flashes and night sweats
- Vaginal dryness and inflammation
- Low estrogen
- Ovarian failure
- Prevention of postmenopausal osteoporosis
Dosage forms
- Pill
- Patch
Price
Lowest price
$226.64
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$31.25
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Side effects
The Prempro (Conjugated Estrogens / Medroxyprogesterone Acetate) FDA package insert doesn’t have numbers about how common side effects are.
16possible side effects
- Breast pain28%
- Lung infection17%
- Stomach pain16%
- Headache13%
- Pain11%
- Swelling of arms and legs10%
- Back pain9%
- Depression8%
- Gas7%
- White or yellow vaginal discharge7%
- Sore throat7%
- Nausea6%
- Stuffy nose6%
- Joint pain5%
- Sinus infection5%
- Itchiness3%
Risks and risk factors
No information currently available
- Endometrial cancer
- Using estrogen for more than one year
- Breast cancer
- Personal or family history of breast cancer
- Using estrogen for more than one year
- Increased risk of blood clots and stroke
- Personal or family history of blood clots
- Smoking
- Obesity
- Systemic lupus erythematosus (SLE)
- Increased risk of heart disease
- Smoking
- Obesity
- High blood pressure
- High blood sugar
- High cholesterol
- Age 50 or older
- Dementia
- Age 65 or older
- Pancreas swelling (pancreatitis)
- High levels of triglycerides