Compare Prempro vs. Depo-Estradiol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats low estrogen and relieves menopause symptoms.

Depo-Estradiol (estradiol cypionate injection) is a good once-a-month option for treating menopause symptoms and low estrogen, as long as you're comfortable with needles.

3.2/ 5 average rating with 109 reviewsforDepo-Estradiol
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  • You only need an injection once a month, which can be less of a hassle than pills, patches, creams, and gels.
  • Your doctor can show you how to inject yourself so you can do it on your own at home.
  • Replenishes estrogen to your whole body and relieves multiple symptoms.
  • Less side effects since lower amounts of estrogen is used compared to the pills.
No information currently available
  • Requires injection with a needle, which can be difficult for some people.
  • Increases your risk of endometrial and breast cancer.
  • If you have an intact uterus, you have to use Depo-Estradiol (estradiol cypionate injection) with another hormone called progestin to lower your risk of uterine cancer.
  • Can't be used in people with liver problems.
  • Can be expensive since it's only available as a brand name product.
Used for
  • Menopause - Moderate to severe abnormal vasomotor function Menopause - Moderate to severe vaginal atrophy - Moderate to severe vulvar atrophy Postmenopausal osteoporosis
  • In women with an intact uterus; Prophylaxis
Dosage forms
  • Pill
  • Injection
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109 reviews so far
saidit'sworth it
saiditworked well
saidit'sa big hassle

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Side effects
The Prempro (Conjugated Estrogens / Medroxyprogesterone Acetate) FDA package insert doesn’t have numbers about how common side effects are.
The Depo-Estradiol (estradiol cypionate injection) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
No information currently available
  • Endometrial cancer
    • Taking estrogen replacement for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen for more than one year
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Aged 50 or older
  • Dementia
    • Aged 65 or older
  • Pancreas swelling (pancreatitis)
    • High levels of triglycerides
See more detailed risks and warnings