Compare Prempro vs. Estrace vaginal cream

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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No information currently available
Relieves vaginal dryness due to menopause.

Estrace vaginal cream (Estradiol vaginal cream) works well to treat menopausal symptoms localized to the vagina.

3.9/ 5 average rating with 15 reviewsforEstrace vaginal cream
Upsides
No information currently available
  • Side-effects are limited compared to estrogen pill since application is localized to the vagina only.
Downsides
No information currently available
  • Method of application can be difficult or uncomfortable compared to a pill that is taken by mouth.
  • It is not effective for hot flashes.
  • The cream is not compatible with certain birth control methods. It can weaken latex (rubber) condoms, cervical caps, and diaphrams so avoid use within 72 hours after a dose.
  • The applicator can be source of infection if not kept clean.
  • Available as a brand name product only.
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Used for
  • Menopause - Moderate to severe abnormal vasomotor function Menopause - Moderate to severe vaginal atrophy - Moderate to severe vulvar atrophy Postmenopausal osteoporosis
  • In women with an intact uterus; Prophylaxis
  • Vaginal dryness and inflammation
Dosage forms
  • Pill
  • Cream
Price
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Reviews
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15 reviews so far
60%
saidit'sworth it
73%
saiditworked well
47%
saidit'sa big hassle

Have you used Estrace vaginal cream (Estradiol vaginal cream)?

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Side effects
The Prempro (Conjugated Estrogens / Medroxyprogesterone Acetate) FDA package insert doesn’t have numbers about how common side effects are.
The Estrace vaginal cream (Estradiol vaginal cream) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
No information currently available
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen for more than one year
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Inflammation of pancreas
    • High levels of triglycerides
See more detailed risks and warnings