Compare Prempro vs. Estring

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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No information currently available
Relieves vaginal dryness due to menopause.

Estring (estradiol vaginal ring) is more convenient than other forms of estrogen therapy since you only have to replace it every 3 months, but it needs to be inserted directly into the vagina.

3.3/ 5 average rating with 56 reviewsforEstring
Upsides
No information currently available
  • Many women find Estring (estradiol vaginal ring) more comfortable to use and easier to apply than creams or gels.
  • Estring (estradiol vaginal ring) may be more convenient since it is dosed once every 3 months compared to alternatives that need to taken daily or twice weekly.
  • Works directly at the site of application and safer than oral estrogen pills.
Downsides
No information currently available
  • Estring (estradiol vaginal ring) may not be the best option if you have a narrow vagina or frequent vaginal infections.
  • The ring can fall out without you noticing.
  • Estring (estradiol vaginal ring) is only available as brand name, so can be expensive.
  • Estring (estradiol vaginal ring) All estrogen therapies increase your risk for uterine cancer, heart problems, and blood clots.
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Used for
  • Menopause - Moderate to severe abnormal vasomotor function Menopause - Moderate to severe vaginal atrophy - Moderate to severe vulvar atrophy Postmenopausal osteoporosis
  • In women with an intact uterus; Prophylaxis
  • Vaginal dryness and inflammation
Dosage forms
  • Pill
  • Vaginal ring
Price
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Reviews
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56 reviews so far
63%
saidit'sworth it
39%
saiditworked well
18%
saidit'sa big hassle

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Side effects
The Prempro (Conjugated Estrogens / Medroxyprogesterone Acetate) FDA package insert doesn’t have numbers about how common side effects are.
20possible side effects
  • Headache
    13%
  • Vaginal discharge
    7%
  • Back pain
    6%
  • Yeast infection
    6%
  • Upper airway infection
    5%
  • Vaginal inflammation
    5%
  • Vaginal discomfort/pain
    5%
  • Arthritis
    4%
  • Trouble sleeping
    4%
  • Stomach pain
    4%
  • Sinus infection
    4%
  • Vaginal bleeding
    4%
  • Bacterial growth in the genitals
    4%
  • Joint pain
    3%
  • Nausea
    3%
  • Flu-like symptoms
    3%
  • Bone pain
    2%
  • Bladder infection
    2%
  • Hot flashes
    2%
  • Stress
    2%
See more detailed side effects
Risks and risk factors
No information currently available
  • Uterine cancer
    • Using estrogen for more than one year
    • Higher dose of estrogen
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen and progestin for more than one year
  • Blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Inflammation of pancreas (pancreatitis)
    • High levels of triglycerides
See more detailed risks and warnings