Compare Prempro vs. Vivelle-Dot

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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No information currently available
Relieves menopausal symptoms.

Vivelle-Dot (Estradiol patch) is an estrogen patch that may be easier and more convenient to use than the pill or gel form.

Upsides
No information currently available
  • Good choice if you want to avoid daily dosing of the pill or gel form.
  • Available in wider variety of strengths compared to other estrogen patches.
Downsides
No information currently available
  • Other estrogen patches are dosed once weekly and may be more convenient than Vivelle-Dot (Estradiol patch).
  • Patches can fall off.
  • Estrogen therapy is associated with serious risks for uterine cancer, breast cancer, and blood clots. Don't start treatment until you have had a thorough discussion of the risks and benefits with your doctor.
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Used for
  • Menopause - Moderate to severe abnormal vasomotor function Menopause - Moderate to severe vaginal atrophy - Moderate to severe vulvar atrophy Postmenopausal osteoporosis
  • In women with an intact uterus; Prophylaxis
  • Hot flashes
  • Vaginal dryness and inflammation
  • Low estrogen
  • Prevention of osteoporosis in menopausal women
Dosage forms
  • Pill
  • Patch
Price
Lowest price
$173.28
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Lowest price
$35.00
Find instant savings near you
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Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
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Reviews
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Side effects
The Prempro (Conjugated Estrogens / Medroxyprogesterone Acetate) FDA package insert doesn’t have numbers about how common side effects are.
20possible side effects
  • Headache
    26%
  • Breast pain
    13%
  • Back pain
    11%
  • Menstrual bleeding
    11%
  • Influenza
    8%
  • Common cold
    8%
  • Nausea
    5%
  • Pain
    5%
  • Sinus infection
    5%
  • Lung infection
    5%
  • Neck pain
    5%
  • Limb pain
    5%
  • Nasal congestion
    5%
  • Joint pain
    4%
  • Depression
    3%
  • Constipation
    2%
  • Flu-like symptoms
    2%
  • Sinus headache
    2%
  • Anxiety
    2%
  • Trouble sleeping
    2%
See more detailed side effects
Risks and risk factors
No information currently available
  • Uterine cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen for more than one year
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Inflammation of pancreas
    • High levels of triglycerides
See more detailed risks and warnings
Learn more about Prempro (Conjugated Estrogens / Medroxyprogesterone Acetate)
Learn more about Vivelle-Dot (Estradiol patch)