Compare Prevacid vs. Alka-Seltzer

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats heartburn and stomach ulcers.

Prevacid (lansoprazole) is an effective and inexpensive acid reducer commonly used to provide heartburn relief and help heal ulcers.

4.0/ 5 average rating with 21 reviewsforPrevacid
Relieves symptoms of indigestion and pain

Alka-Seltzer (aspirin / citric acid / sodium bicarbonate) provides quick relief for heartburn, upset stomach, headaches, and general pain. However, you have to take it a few times a day to continue getting relief of your symptoms.

3.9/ 5 average rating with 1055 reviewsforAlka-Seltzer
Upsides
  • Most people can take Prevacid (lansoprazole) without any noticeable day-to-day side effects.
  • Comes in a dissolving tablet to be placed on the tongue if you cannot or do not like to swallow pills.
  • Prevacid (lansoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Prevacid (lansoprazole) is available over-the-counter and as inexpensive, generic options.
  • Alka-Seltzer (aspirin / citric acid / sodium bicarbonate) is a great option if you have an upset stomach and a headache or body aches at the same time.
  • Alka-Seltzer (aspirin / citric acid / sodium bicarbonate) works quickly to relieve symptoms.
  • Available over the counter without a prescription.
  • Also, available as generic and is fairly cheap.
Downsides
  • Doesn't start working right away like some other acid reducers (Tums, Rolaids, or Maalox).
  • May not be the best choice for patients 65 years of age and older due to risk of bone fractures and C. diff infection (bacterial).
  • Is used if you have frequent heartburns that occur more than 2 days per week. Speak to your doctor or pharmacist if you only have occasional heartburn.
  • The effects of this medication don't last very long. Other medicines, like Zantac (H2 blockers) and omeprazole (proton pump inhibitors), work better and last longer.
  • Because this medicine contains aspirin, it raises the risk of bleeding, especially if you take any other blood thinning medicines.
  • People who are allergic to aspirin can't use this medication.
  • May not like the taste or fizz.
  • Kids or teenagers should not use Alka-Seltzer (aspirin / citric acid / sodium bicarbonate) unless instructed by a doctor.
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Used for
Dosage forms
  • Extended release
  • Dissolving tablet extended release
  • Liquid
  • Effervescent tablet
Price
No pricing information available
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Reviews
21 reviews so far
71%
saidit'sworth it
71%
saiditworked well
19%
saidit'sa big hassle

Have you used Prevacid (lansoprazole)?

Leave a review
1055 reviews so far
81%
saidit'sworth it
52%
saiditworked well
8%
saidit'sa big hassle

Have you used Alka-Seltzer (aspirin / citric acid / sodium bicarbonate)?

Leave a review
Side effects
2possible side effects
  • Diarrhea
    4%
  • Abdominal pain
    2%
See more detailed side effects
The Alka-Seltzer (aspirin / citric acid / sodium bicarbonate) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Stomach cancer
  • Acute kidney damage
  • Clostridium difficile associated diarrhea (CDAD)
  • Bone fractures
    • High dose Prevacid (lansoprazole)
    • Long-term treatment with Prevacid (lansoprazole)
    • Low bone mineral density
    • Older age
  • Lupus
  • Low vitamin or mineral levels
See more detailed risks and warnings
  • Taking the wrong medication
    • Not reading the drug label
  • Brain damage or death from Reye's Syndrome
    • Children 18 years or younger recovering from viral infections
  • High blood sodium levels
    • Current kidney disease
    • Dialysis
    • Age 65 or older
    • Hyperparathyroidism
    • Use of other medicines that can cause kidney damage
  • May worsen heart or kidney problems
    • Congestive heart failure (CHF)
    • High blood pressure
    • Current kidney disease
    • Kidney dialysis
  • Stomach Bleeding
    • History of stomach bleeding or ulcers
    • Age 60 or older
    • Also taking other blood thinners
    • Drinking 3 or more alcoholic drinks a day
  • Harm to unborn babies
    • Pregnancy
See more detailed risks and warnings