Compare Prevacid vs. Pepto-Bismol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats heartburn and stomach ulcers.

Prevacid (lansoprazole) is an effective and inexpensive acid reducer commonly used to provide heartburn relief and help heal ulcers.

4.0/ 5 average rating with 21 reviewsforPrevacid
Relieves heartburn, upset stomach, and diarrhea.

Pepto-Bismol (bismuth subsalicylate) can help for many stomach and intestinal problems, but may take longer to work compared to some other anti-diarrheal medicines.

3.9/ 5 average rating with 1376 reviewsforPepto-Bismol
Upsides
  • Most people can take Prevacid (lansoprazole) without any noticeable day-to-day side effects.
  • Comes in a dissolving tablet to be placed on the tongue if you cannot or do not like to swallow pills.
  • Prevacid (lansoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Prevacid (lansoprazole) is available over-the-counter and as inexpensive, generic options.
  • Pepto-Bismol (bismuth subsalicylate) works well to alleviate stomach and intestinal problems and doesn't have many side effects.
  • Comes in easy to take chewable pills or liquid, if you do not like swallowing pills.
  • Is inexpensive and available over the counter.
  • Coupons are available. Speak to your doctor or pharmacist.
Downsides
  • Doesn't start working right away like some other acid reducers (Tums, Rolaids, or Maalox).
  • May not be the best choice for patients 65 years of age and older due to risk of bone fractures and C. diff infection (bacterial).
  • Is used if you have frequent heartburns that occur more than 2 days per week. Speak to your doctor or pharmacist if you only have occasional heartburn.
  • May not be as strong as other anti-diarrheal or antacid medications.
  • Should not be used for more than 2 days if your diarrhea does not go away or if you have a fever.
  • For symptoms other than diarrhea, should not be used for more than 7 days without your doctor's approval. Speak to your doctor if symptoms persist.
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Used for
Dosage forms
  • Extended release
  • Dissolving tablet extended release
  • Liquid
  • Chewable tablet
  • Liquid
  • Pill
Price
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Reviews
21 reviews so far
71%
saidit'sworth it
71%
saiditworked well
19%
saidit'sa big hassle

Have you used Prevacid (lansoprazole)?

Leave a review
1376 reviews so far
84%
saidit'sworth it
48%
saiditworked well
6%
saidit'sa big hassle

Have you used Pepto-Bismol (bismuth subsalicylate)?

Leave a review
Side effects
2possible side effects
  • Diarrhea
    4%
  • Abdominal pain
    2%
See more detailed side effects
The Pepto-Bismol (bismuth subsalicylate) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Stomach cancer
  • Acute kidney damage
  • Clostridium difficile associated diarrhea (CDAD)
  • Bone fractures
    • High dose Prevacid (lansoprazole)
    • Long-term treatment with Prevacid (lansoprazole)
    • Low bone mineral density
    • Older age
  • Lupus
  • Low vitamin or mineral levels
See more detailed risks and warnings
  • Reye's syndrome
    • Children or teenagers that have or are recovering from flu/flu-like symptoms or chickenpox
  • Allergy to salicylates
    • Aspirin allergy
    • NSAID allergy
  • Hearing problems
    • Age 60 or older
  • Drug Interactions
    • Anticoagulants
    • Aspirin-containing medications
See more detailed risks and warnings