Compare Prezista vs. Evotaz

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats HIV infection.

Prezista (darunavir) is one of the first-choices for treatment of HIV because it has fewer side-effects compared to other medicines that work like it.

Treats HIV infection.

Although not a first choice due to its side effects, Evotaz (atazanavir / cobicistat) is still a good alternative for use with other medications to treat HIV.

Upsides
  • Prezista (darunavir) is a good choice for those newly diagnosed HIV.
  • May be used in combination with other HIV medicines if you have been accidentally exposed to HIV by a needle-stick.
  • Available as a liquid solution and can be used for children as young as 3 years old.
  • If first-line choices for HIV medications are not an option, Evotaz (atazanavir / cobicistat) is a good alternative to consider.
  • Taken only once daily.
  • Evotaz (atazanavir / cobicistat) is a combination of two different medications for HIV.
Downsides
  • Need to take together with a booster like Norvir.
  • Doesn't work as well for those with longstanding HIV.
  • Can affect your cholestorol and blood sugar levels.
  • Evotaz (atazanavir / cobicistat) can interact with other medications so you should talk to your doctor before adding new treatments.
  • Evotaz (atazanavir / cobicistat) can cause changes to heart rhythm.
  • Evotaz (atazanavir / cobicistat) can affect your blood sugar levels, causing diabetes or worsening diabetes if you have it already.
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Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
Price
Lowest price
$1750.12
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Lowest price
$1592.03
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Reviews
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Side effects
12possible side effects
  • Diarrhea
    14%
  • Headache
    7%
  • Nausea
    7%
  • Rash
    7%
  • Abdominal pain
    6%
  • Vomiting
    5%
  • Physical weakness
    3%
  • Loss of appetite
    2%
  • Abdominal swelling
    2%
  • Indigestion
    2%
  • Fatigue
    2%
  • Diabetes
    2%
See more detailed side effects
6possible side effects
  • Yellowing of skin
    6%
  • Rash
    5%
  • Yellowing of eyes
    4%
  • Nausea
    2%
  • Diarrhea
    2%
  • Headache
    2%
See more detailed side effects
Risks and risk factors
  • Liver damage
    • History of liver damage
    • Alcohol intake
  • Severe skin reactions
  • Sulfonamide allergy
  • Fat redistribution
    • HIV treatment
  • Immune recovery syndrome
    • HIV
    • Exposure to other infections
    • Start of a new HIV medication
    • Change in HIV therapy
  • Diabetes
    • Use of protease inhibitors
    • Diabetes
See more detailed risks and warnings
  • Heartbeat problems
    • History of heartbeat problems
  • Kidney problems
    • Taking tenofovir DF
  • Kidney stones or gallstones
  • Immune reconstitution syndrome
    • HIV
    • Exposure to other infections
    • Start of a new HIV medication
    • Change in HIV therapy
  • Liver damage
    • History of liver damage
    • Hepatitis B or C
  • Severe allergic reactions
    • Prior severe allergic reaction to Evotaz (atazanavir / cobicistat) or any of its individual drug components.
See more detailed risks and warnings
Learn more about Prezista (darunavir)
Learn more about Evotaz (atazanavir / cobicistat)