Compare Prezista vs. Invirase
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Treats HIV infection.
Prezista (darunavir) is one of the first-choices for treatment of HIV because it has fewer side-effects compared to other medicines that work like it.
Works with other medicines to treat HIV infection.
Invirase (saquinavir) is not a first choice medicine for HIV because other medicines similar to Invirase (saquinavir) work better with fewer side effects and with less pills to take every day.
Upsides
- Prezista (darunavir) is a good choice for those newly diagnosed HIV.
- May be used in combination with other HIV medicines if you have been accidentally exposed to HIV by a needle-stick.
- Available as a liquid solution and can be used for children as young as 3 years old.
- If you have trouble swallowing capsules, they can be opened and mixed with syrup or jam.
- People ages 16 and older can use this medicine.
Downsides
- Need to take together with a booster like Norvir.
- Doesn't work as well for those with longstanding HIV.
- Can affect your cholestorol and blood sugar levels.
- Have to take at least 4 pills to reach your daily dose, along with all the other medications you are taking for HIV treatment.
- Invirase (saquinavir) interacts with many other medications. This interaction can be harmful.
- Can raise your blood sugar and cholesterol levels.
- If you have a history of heart problems, Invirase (saquinavir) can put you at risk for developing unusual heart rhythms.
- Only use ritonavir to boost Invirase (saquinavir), not Tybost (cobicistat).
Used for
- HIV infection
- HIV prevention
Dosage forms
- Pill
- Liquid
- Pill
Price
Lowest price
$2053.12
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$1199.53
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Side effects
12possible side effects
- Diarrhea14%
- Headache7%
- Nausea7%
- Rash7%
- Abdominal pain6%
- Vomiting5%
- Physical weakness3%
- Loss of appetite2%
- Abdominal swelling2%
- Indigestion2%
- Fatigue2%
- Diabetes2%
18possible side effects
- Nausea11%
- Diarrhea8%
- Vomiting7%
- Abdominal pain6%
- Fatigue6%
- Changes in fat distribution5%
- Pneumonia5%
- Diabetes or increased blood sugar3%
- Fever3%
- Bronchitis3%
- Influenza3%
- Sinus infections3%
- Rash3%
- Itching3%
- Constipation2%
- Back pain2%
- Dry lips/skin2%
- Eczema2%
Risks and risk factors
- Liver damage
- History of liver damage
- Alcohol intake
- Severe skin reactions
- Sulfonamide allergy
- Fat redistribution
- HIV treatment
- Immune recovery syndrome
- HIV
- Exposure to other infections
- Start of a new HIV medication
- Change in HIV therapy
- Diabetes
- Use of protease inhibitors
- Diabetes
- Heart rhythm problems
- Use with other QT or PR prolonging drugs
- History of heart disease
- Low potassium or magnesium levels
- Drug interactions
- Liver damage
- History of liver damage
- Hepatitis B or C
- Chronic alcoholism
- New or worsening diabetes
- Use of protease inhibitors
- Diabetes
- High cholesterol and fat in the blood
- Immune reconstitution syndrome
- HIV
- Exposure to other infections
- Start of a new HIV medication
- Change in HIV therapy