Compare Prezista vs. Reyataz

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats HIV infection.

Prezista (darunavir) is one of the first-choices for treatment of HIV because it has fewer side-effects compared to other medicines that work like it.

Treats HIV infection.

Reyataz (atazanavir) works well with other HIV medicines to treat HIV, but it's not a first-line choice due to its side effects, and you must take it with food.

Upsides
  • Prezista (darunavir) is a good choice for those newly diagnosed HIV.
  • May be used in combination with other HIV medicines if you have been accidentally exposed to HIV by a needle-stick.
  • Available as a liquid solution and can be used for children as young as 3 years old.
  • If first-line choices for HIV medicines are not an option, Reyataz (atazanavir) is a good alternative to consider.
  • Conveniently taken once daily.
  • Available in powder form for mixing if pills are hard to swallow.
  • A safer choice than Prezista (darunavir) or Prezcobix (darunavir/cobicistat) for people with heart problems.
  • Good choice for people with kidney problems.
Downsides
  • Need to take together with a booster like Norvir.
  • Doesn't work as well for those with longstanding HIV.
  • Can affect your cholestorol and blood sugar levels.
  • Reyataz (atazanavir) can interact with many other medicines. Talk to your doctor or pharmacist before starting or stopping medicines.
  • Not a good choice for people with uncontrolled diabetes, liver problems, or history of gallstones or kidney stones.
  • Needs to be taken with other HIV medicines.
  • Reyataz (atazanavir) powder contains phenylalanine, which is harmful to people who can't digest phenylalanine (i.e., phenylketonuria).
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Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Powder
Price
Lowest price
$1578.13
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Reviews
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Side effects
12possible side effects
  • Diarrhea
    14%
  • Headache
    7%
  • Nausea
    7%
  • Rash
    7%
  • Abdominal pain
    6%
  • Vomiting
    5%
  • Physical weakness
    3%
  • Loss of appetite
    2%
  • Abdominal swelling
    2%
  • Indigestion
    2%
  • Fatigue
    2%
  • Diabetes
    2%
See more detailed side effects
13possible side effects
  • Nausea
    14%
  • Yellowing of skin and eyes
    9%
  • Rash
    7%
  • Headache
    6%
  • Vomiting
    4%
  • Stomach pain
    4%
  • Burning or tingling in hands, arms, legs, or feet
    4%
  • Muscle pain
    4%
  • Trouble sleeping
    3%
  • Diarrhea
    3%
  • Dizziness
    2%
  • Fever
    2%
  • Depression
    2%
See more detailed side effects
Risks and risk factors
  • Liver damage
    • History of liver damage
    • Alcohol intake
  • Severe skin reactions
  • Sulfonamide allergy
  • Fat redistribution
    • HIV treatment
  • Immune recovery syndrome
    • HIV
    • Exposure to other infections
    • Start of a new HIV medication
    • Change in HIV therapy
  • Diabetes
    • Use of protease inhibitors
    • Diabetes
See more detailed risks and warnings
  • Changes in heartbeat
    • History of heartbeat problems
    • Taking other medicines that can affect your heartbeat
  • High bilirubin levels
  • New or worsening diabetes
    • Diabetes
  • Immune reconstitution syndrome
    • HIV
    • Exposure to other infections
    • Start of a new HIV medicine
    • Change in HIV therapy
  • Liver damage
    • History of liver damage
    • Hepatitis B or C
  • Severe skin reactions
See more detailed risks and warnings