Compare primaquine vs. doxycycline

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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primaquine

Prescription only

Vibramycin (doxycycline)

Prescription only
Treats and prevents malaria.

primaquine can effective in treating malarial infections, but there are many precautions while taking primaquine.

Treats bacterial infections.

Vibramycin (doxycycline) is good for treating many bacterial infections, but can increase your skin's sensitivity to sunlight and make you more likely to get a sunburn or rash.

3.2/ 5 average rating with 112 reviewsfordoxycycline
Upsides
  • primaquine is a good choice to treat and prevent malaria in some parts of the world.
  • primaquine only has to be taken once a day.
  • Vibramycin (doxycycline) is a good alternative for some types of bacterial infections for people who are allergic to penicillin.
  • Available in generic.
  • Available as a liquid for those who have trouble swallowing.
  • Vibramycin (doxycycline) is safe for people age 65 or older and those who have kidney problems.
Downsides
  • primaquine has many drug interactions.
  • You must be tested for G6PD before taking primaquine.
  • primaquine can cause many severe side effects.
  • Vibramycin (doxycycline) makes your skin more sensitive to the sun.
  • Vibramycin (doxycycline) can make some birth control less effective, so you may have to use barrier methods (like condoms) while on it.
  • Vitamins, iron supplements, or antacids can't be taken at the same time as Vibramycin (doxycycline).
  • Vibramycin (doxycycline) can cause severe diarrhea that is usually watery and bloody, as late as up to 2 months after finishing the medicine.
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Used for
Dosage forms
  • Pill
  • Pill
  • Delayed release pill
  • Liquid
Price
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Reviews
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112 reviews so far
49%
saidit'sworth it
36%
saiditworked well
24%
saidit'sa big hassle

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Side effects
The primaquine FDA package insert doesn’t have numbers about how common side effects are.
The Vibramycin (doxycycline) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Blood problems
    • G6PD deficiency
    • Rheumatoid arthritis
    • Lupus
    • Other drugs that can suppress your bone marrow
  • Heart problems
    • Pre-existing heart conduction abnormalities
    • Other medicines that can cause QT prolongation
    • Electrolyte problems
  • Many drug interactions
See more detailed risks and warnings
  • Color changes in teeth of young children and unborn babies
    • Age 8 or younger
    • Women in their last half of pregnancy
    • Infants
  • Severe diarrhea
    • Using Vibramycin (doxycycline) for a long period of time
  • Sunburn or rash
    • Being in the sun for a long period of time
    • Using tanning salons
  • Harm to fetus (unborn baby)
    • Women who can potentially or want to become pregnant
    • Pregnant women
See more detailed risks and warnings