Compare Pristiq vs. Effexor
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Improves mood.
Pristiq (desvenlafaxine) is an effective medicine for treating depression, but it is more expensive than many other medicines that work just like it.
●●●●●
3.5/ 5 average rating with 196 reviewsforPristiq
Improves mood and helps you relax.
Effexor (venlafaxine) is good for treating depression and anxiety, but it can cause more withdrawal symptoms if you stop suddenly compared to other antidepressants.
●●●●●
3.7/ 5 average rating with 577 reviewsforEffexor
Upsides
- You only need to take Pristiq (desvenlafaxine) once a day.
- May be taken with or without food.
- Less sedating than other anti-depressants.
- Effexor (venlafaxine) effectively treats depression, anxiety, and panic disorder.
- Effexor (venlafaxine) causes more sleepiness than other antidepressants, so it's beneficial for people who have trouble sleeping.
- Effexor (venlafaxine) might work when other antidepressants haven't worked since it affects two chemicals in the brain that impact your mood.
- Effexor (venlafaxine) has several uses, which may be good for people with multiple conditions.
- Effexor (venlafaxine) is available in generic, which is cheaper.
Downsides
- Like most anti-depressants, full effect on mood takes up to 12 weeks.
- Can increase the risk of suicidal thoughts and/or behavior in yound adults 24 years and younger.
- Can affect your sex drive and ability to get an erection.
- Effexor (venlafaxine) can cause side effects such as decreased libido and increased blood pressure.
- Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people aged 24 years or younger.
- Compared to other antidepressants, it's more likely to cause unpleasant withdrawal symptoms if you suddenly stop taking it and can causes more sleepiness.
Used for
Dosage forms
- Extended-release pill
- Pill
- Extended release
Price
Lowest price
$19.90
Find instant savings near youLowest price
$11.44
Find instant savings near youWant to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Learn more
Reviews
196 reviews so far
53%
saidit'sworth it
49%
saiditworked well
23%
saidit'sa big hassle
Have you used Pristiq (desvenlafaxine)?
Leave a review577 reviews so far
62%
saidit'sworth it
51%
saiditworked well
23%
saidit'sa big hassle
Have you used Effexor (venlafaxine)?
Leave a reviewSide effects
17possible side effects
- Nausea22%
- Dizziness13%
- Dry mouth11%
- Excessive sweating10%
- Constipation9%
- Inability to sleep9%
- Tiredness7%
- Decreased appetite5%
- Drowsiness4%
- Vomiting3%
- Anxiety3%
- Blurry vision3%
- Tremor2%
- Abnormal dreams2%
- Dilated pupils2%
- Vertigo2%
- Ringing in ears2%
39possible side effects
- Nausea37%
- Headache25%
- Drowsiness23%
- Dry mouth22%
- Dizziness19%
- Difficulty sleeping18%
- Constipation15%
- Nervousness13%
- Weakness12%
- Sweating12%
- Abnormal ejaculation/orgasm12%
- Loss of appetite11%
- Diarrhea8%
- Infection6%
- Vomiting6%
- Anxiety6%
- Blurred vision6%
- Impotence6%
- Indigestion5%
- Tremor5%
- Abnormal dreams4%
- Chills3%
- Rash3%
- Gas3%
- Stiff muscles3%
- Prickling/burning sensation3%
- Yawn3%
- Increased urination3%
- Chest pain2%
- Trauma2%
- Increased blood pressure2%
- Increased heart rate2%
- Decreased libido2%
- Agitation2%
- Confusion2%
- Thinking abnormal2%
- Changes in taste2%
- Ringing in the ears2%
- Dilation of pupils2%
Risks and risk factors
- Suicidal thoughts or behavior
- Age 24 or younger
- Serotonin syndrome
- Taking other medicines that also increase serotonin activity: Antidepressants (SSRIs, SNRIs, TCAs)
- lithium
- tramadol
- Imitrex
- Remeron
- Lexapro
- Dilaudid
- Increased blood pressure
- People with a history of high blood pressure or other heart conditions
- Increased bleeding risk
- Taking NSAIDS, blood thinners, or aspirin
- Low sodium levels in blood
- Older people
- Taking diuretics
- Stopping Pristiq (desvenlafaxine) too quickly
- Taking the medicine for a long time
- Stopping Pristiq (desvenlafaxine) too quickly
- Suicidal thoughts or behavior
- Age 24 years or younger
- Serotonin syndrome
- Taking tricyclic antidepressants, lithium, tramadol, fentanyl, amphetamines, certain headache medications (triptans), St. John's Wort
- Withdrawal
- Stopping Effexor (venlafaxine) suddenly
- Increased bleeding
- Taking other blood-thinning drugs (including aspirin, NSAIDs such as Advil, warfarin)
- Increased blood pressure
- Bipolar disorder
- History of bipolar disorder
- At risk for bipolar disorder