Compare Prograf vs. Afinitor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Prograf (tacrolimus)

Prescription only

Afinitor (everolimus)

Prescription only
Prevents rejection of a transplanted organ.

Prograf (tacrolimus) is a good medicine that prevents rejection of an organ transplant, but you will need to be on it lifelong.

Treats different types of cancer.

Treats different types of cancer, but can cause uncomfortable side effects.

Upsides
  • Prevents your body from rejecting a transplanted organ.
  • Available as an extended-release pill, so it can be taken just once daily.
  • Less cosmetic side-effects than other anti-rejection medicine like cyclosporine.
  • Afinitor (everolimus) comes as a pill rather than an injection, unlike some other cancer drugs.
Downsides
  • Regular blood tests are required for monitoring while on Prograf (tacrolimus).
  • Can cause a lot of side-effects, such as high blood sugar, high blood pressure, mental status changes, and kidney damage, especially with lifelong use.
  • Increases your risk of infection and certain cancers.
  • Afinitor (everolimus) has many uncomfortable and potentially intolerable side effects.
  • You may be more prone to infections and take longer to recover from a wound while taking Afinitor (everolimus).
  • Some prescription medications, vitamins and supplements can interfere with how Afinitor (everolimus) works.
  • Afinitor (everolimus) might not be the best option if you have liver problems.
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Used for
  • Prevention of heart transplant rejection
  • Prevention of liver transplant rejection
  • Prevention of kidney transplant rejection
  • Lung transplant rejection
  • Bowel transplant rejection
  • Graft-versus-host disease
Dosage forms
  • Pill
  • Extended release
  • Injection
  • Pill
Price
Lowest price
$14450.00
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Reviews
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Side effects
13possible side effects
  • High blood pressure
    62%
  • Kidney Function Abnormal
    56%
  • Anemia
    50%
  • Low white blood cells
    48%
  • Viral infection
    32%
  • Diabetes Mellitus
    26%
  • Infection
    24%
  • High blood sugar
    23%
  • High cholesterol
    18%
  • Bronchitis
    17%
  • Urinary Tract Infection
    16%
  • Fluid around the heart
    15%
  • Tremor
    15%
See more detailed side effects
34possible side effects
  • Mouth sores
    70%
  • Rash
    59%
  • Diarrhea
    50%
  • Tiredness
    45%
  • Swelling
    39%
  • Stomach pain
    36%
  • Nausea
    32%
  • Fever
    31%
  • Decreased appetite
    30%
  • Headache
    30%
  • Vomiting
    28%
  • Weight loss
    28%
  • Common cold
    25%
  • Cough
    25%
  • Nosebleed
    22%
  • Nail disorder
    22%
  • Itchy skin
    21%
  • Difficulty breathing
    20%
  • Weakness
    19%
  • Decreased taste sensitivity
    19%
  • Lung inflammation
    17%
  • Urinary tract infection
    16%
  • Joint pain
    15%
  • Back pain
    15%
  • Constipation
    14%
  • Pain in extremity
    14%
  • Difficulty sleeping
    14%
  • Dry skin
    13%
  • High blood pressure
    13%
  • Dizziness
    12%
  • Dry mouth
    11%
  • Throat pain
    11%
  • Diabetes
    10%
  • Muscle spasms
    10%
See more detailed side effects
Risks and risk factors
  • Serious infections
    • Taking other immunosuppressant drugs
    • Age 60 or older
    • Weak immune system
  • Cancer
    • Taking Prograf (tacrolimus) for a long time
  • Heart problems
    • History of heart problems
    • Taking drugs that interact with Prograf (tacrolimus)
    • High Prograf (tacrolimus) blood levels
  • Kidney damage
    • Poor kidney function
    • Taking other drugs that can damage the kidneys
    • Taking drugs that interact with Prograf (tacrolimus)
  • Diabetes
    • African-American descent
    • Hispanic descent
  • Increased risk of death in female liver transplant patients taking extended-release Prograf (tacrolimus)
    • Females using Astagraf XL
    • Liver transplantation
See more detailed risks and warnings
  • Infection
  • Kidney disease
  • Lung problems
  • Reaction to live vaccines
  • Swelling of the airways or tongue
    • Taking ACE inhibitor
  • Mouth ulcers
See more detailed risks and warnings