Compare Prograf vs. Afinitor
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Prevents rejection of a transplanted organ.
Prograf (tacrolimus) is a good medicine that prevents rejection of an organ transplant, but you will need to be on it lifelong.
Treats different types of cancer.
Treats different types of cancer, but can cause uncomfortable side effects.
Upsides
- Prevents your body from rejecting a transplanted organ.
- Available as an extended-release pill, so it can be taken just once daily.
- Less cosmetic side-effects than other anti-rejection medicine like cyclosporine.
- Afinitor (everolimus) comes as a pill rather than an injection, unlike some other cancer drugs.
Downsides
- Regular blood tests are required for monitoring while on Prograf (tacrolimus).
- Can cause a lot of side-effects, such as high blood sugar, high blood pressure, mental status changes, and kidney damage, especially with lifelong use.
- Increases your risk of infection and certain cancers.
- Afinitor (everolimus) has many uncomfortable and potentially intolerable side effects.
- You may be more prone to infections and take longer to recover from a wound while taking Afinitor (everolimus).
- Some prescription medications, vitamins and supplements can interfere with how Afinitor (everolimus) works.
- Afinitor (everolimus) might not be the best option if you have liver problems.
Used for
- Prevention of heart transplant rejection
- Prevention of liver transplant rejection
- Prevention of kidney transplant rejection
- Lung transplant rejection
- Bowel transplant rejection
- Graft-versus-host disease
- Breast cancer
- Neuroendocrine tumors
- Renal angiomyolipoma
- Renal cell carcinoma
- Subependymal giant cell astrocytoma
- Waldenstrom macroglobulinemia
Dosage forms
- Pill
- Extended release
- Injection
- Pill
Price
Lowest price
$449.60
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$14450.00
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Side effects
13possible side effects
- High blood pressure62%
- Kidney Function Abnormal56%
- Anemia50%
- Low white blood cells48%
- Viral infection32%
- Diabetes Mellitus26%
- Infection24%
- High blood sugar23%
- High cholesterol18%
- Bronchitis17%
- Urinary Tract Infection16%
- Fluid around the heart15%
- Tremor15%
34possible side effects
- Mouth sores70%
- Rash59%
- Diarrhea50%
- Tiredness45%
- Swelling39%
- Stomach pain36%
- Nausea32%
- Fever31%
- Decreased appetite30%
- Headache30%
- Vomiting28%
- Weight loss28%
- Common cold25%
- Cough25%
- Nosebleed22%
- Nail disorder22%
- Itchy skin21%
- Difficulty breathing20%
- Weakness19%
- Decreased taste sensitivity19%
- Lung inflammation17%
- Urinary tract infection16%
- Joint pain15%
- Back pain15%
- Constipation14%
- Pain in extremity14%
- Difficulty sleeping14%
- Dry skin13%
- High blood pressure13%
- Dizziness12%
- Dry mouth11%
- Throat pain11%
- Diabetes10%
- Muscle spasms10%
Risks and risk factors
- Serious infections
- Taking other immunosuppressant drugs
- Age 60 or older
- Weak immune system
- Cancer
- Taking Prograf (tacrolimus) for a long time
- Heart problems
- History of heart problems
- Taking drugs that interact with Prograf (tacrolimus)
- High Prograf (tacrolimus) blood levels
- Kidney damage
- Poor kidney function
- Taking other drugs that can damage the kidneys
- Taking drugs that interact with Prograf (tacrolimus)
- Diabetes
- African-American descent
- Hispanic descent
- Increased risk of death in female liver transplant patients taking extended-release Prograf (tacrolimus)
- Females using Astagraf XL
- Liver transplantation
- Infection
- Kidney disease
- Lung problems
- Reaction to live vaccines
- Swelling of the airways or tongue
- Taking ACE inhibitor
- Mouth ulcers