Compare Prograf vs. Rapamune

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prevents rejection of a transplanted organ.

Prograf (tacrolimus) is a good medicine that prevents rejection of an organ transplant, but you will need to be on it lifelong.

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  • Prevents your body from rejecting a transplanted organ.
  • Available as an extended-release pill, so it can be taken just once daily.
  • Less cosmetic side-effects than other anti-rejection medicine like cyclosporine.
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  • Regular blood tests are required for monitoring while on Prograf (tacrolimus).
  • Can cause a lot of side-effects, such as high blood sugar, high blood pressure, mental status changes, and kidney damage, especially with lifelong use.
  • Increases your risk of infection and certain cancers.
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Used for
  • Prevention of heart transplant rejection
  • Prevention of liver transplant rejection
  • Prevention of kidney transplant rejection
  • Lung transplant rejection
  • Bowel transplant rejection
  • Graft-versus-host disease
  • Renal transplant rejection
  • High immunologic risk; Prophylaxis Renal transplant rejection
  • Low to moderate immunologic risk; Prophylaxis
  • Renal transplant rejection
Dosage forms
  • Pill
  • Extended release
  • Injection
  • Pill
  • Liquid
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Side effects
13possible side effects
  • High blood pressure
  • Kidney Function Abnormal
  • Anemia
  • Low white blood cells
  • Viral infection
  • Diabetes Mellitus
  • Infection
  • High blood sugar
  • High cholesterol
  • Bronchitis
  • Urinary Tract Infection
  • Fluid around the heart
  • Tremor
See more detailed side effects
The Rapamune (Sirolimus) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Serious infections
    • Taking other immunosuppressant drugs
    • Age 60 or older
    • Weak immune system
  • Cancer
    • Taking Prograf (tacrolimus) for a long time
  • Heart problems
    • History of heart problems
    • Taking drugs that interact with Prograf (tacrolimus)
    • High Prograf (tacrolimus) blood levels
  • Kidney damage
    • Poor kidney function
    • Taking other drugs that can damage the kidneys
    • Taking drugs that interact with Prograf (tacrolimus)
  • Diabetes
    • African-American descent
    • Hispanic descent
  • Increased risk of death in female liver transplant patients taking extended-release Prograf (tacrolimus)
    • Females using Astagraf XL
    • Liver transplantation
See more detailed risks and warnings
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