Compare Prolia vs. Evista

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Prolia (Denosumab)

Prescription only

Evista (Raloxifene)

Prescription only
Prevents bone loss.

Prolia (Denosumab) is an effective and convenient treatment for osteoporosis if other options haven’t worked or aren’t appropriate for you. There’re risks of some rare side effects, so make sure you're following up with your doctor regularly.

3.6/ 5 average rating with 15 reviewsforProlia
Prevents bone loss and lowers your risk of breast cancer.

Evista (Raloxifene) is effective at reducing bone loss and lowering the risk of breast cancer in postmenopausal women, but does carry the risk of blood clots.

Upsides
  • Prolia (Denosumab) is effective at preventing bone loss, making your bones stronger and lowering your chance of getting a fracture.
  • Only need to get an injection every 6 months, so you don’t have to remember to take something every day.
  • Evista (Raloxifene) doesn’t affect the breast or uterus the same way that estrogen does, so the risk of cancer is much lower.
  • Taking Evista (Raloxifene) with calcium and vitamin D improves spine and hip bone health and lowers the risk of fractures.
  • Lowers total cholesterol and low-density lipoprotein (LDL) cholesterol (the bad cholesterol).
Downsides
  • Approved for women only after they’ve reached menopause. Don’t use this if you’re pregnant or planning to become pregnant.
  • Can lower blood calcium levels. You might need to take calcium supplements to prevent this.
  • Not available as a generic.
  • Can only take Evista (Raloxifene) once you’re in menopause. You can't take it if you're pregnant or breastfeeding.
  • Evista (Raloxifene) isn’t as effective as tamoxifen at lowering the risk of invasive breast cancer.
  • Shouldn’t take it with any other forms of estrogen (pills, patches, or injection).
  • It doesn’t increase bone strength as much as estrogen does and isn’t effective for treating hot flashes.
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Used for
Dosage forms
  • Injection
  • Pill
Price
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Reviews
15 reviews so far
33%
saidit'sworth it
40%
saiditworked well
27%
saidit'sa big hassle

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Side effects
27possible side effects
  • Back pain
    35%
  • Pain in extremity
    12%
  • Musculoskeletal pain
    8%
  • Hypercholesterolemia
    7%
  • Cystitis
    6%
  • Vertigo
    5%
  • Edema peripheral
    5%
  • Upper respiratory tract infection
    5%
  • Sciatica
    5%
  • Pneumonia
    4%
  • Bone pain
    4%
  • Anemia
    3%
  • Angina pectoris
    3%
  • Abdominal pain upper
    3%
  • Myalgia
    3%
  • Insomnia
    3%
  • Rash
    3%
  • Atrial fibrillation
    2%
  • Flatulence
    2%
  • Gastroesophageal reflux disease
    2%
  • Asthenia
    2%
  • Pharyngitis
    2%
  • Herpes zoster
    2%
  • Spinal osteoarthritis
    2%
  • Pruritus
    2%
  • Mortality
    2%
  • Adverse events
    2%
See more detailed side effects
6possible side effects
  • Any side effect
    25%
  • Peripheral edema
    14%
  • Muscle spasms/leg cramps
    12%
  • Hot Flashes
    8%
  • Cholelithiasis
    3%
  • Venous thromboembolic events
    2%
See more detailed side effects
Risks and risk factors
  • Leg bone fractures
    • Taking steroids
  • Hypersensitivity (allergic) reactions
  • Low calcium blood levels
    • Kidney problems
    • Not taking calcium supplements
    • Taking other medicines that can lower calcium blood levels
    • History of hypoparathyroidism (low levels of parathyroid hormone)
  • Infection
    • Weak immune system
    • Taking medicines that block your immune system (such as transplant medications or steroids)
  • Problems in the jaw bone
    • Oral or dental surgery
    • Cancer diagnosis
    • Taking steroids or chemotherapy
    • Poor oral hygiene
  • Pain in the bones and muscles
See more detailed risks and warnings
  • Increased risk of stroke
    • History of stroke
    • Heart and blood vessel problems
    • History of mini stroke (TIA)
    • Atrial fibrillation
    • Smoking
    • High blood pressure
  • Increased risk of blood clots
  • Elevated triglycerides (fats in blood)
    • History of high triglycerides
  • Worsening kidney or liver function
See more detailed risks and warnings