Compare Provera vs. Estrace vaginal cream

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Regulates your menstrual cycle and supplements estrogen treatments for menopause.

Provera (Medroxyprogesterone) works well to regulate your menstrual cycle and stop irregular bleeding. It also protects the uterus from estrogen's harmful effects.

Relieves vaginal dryness due to menopause.

Estrace vaginal cream (Estradiol vaginal cream) works well to treat menopausal symptoms localized to the vagina.

3.9/ 5 average rating with 15 reviewsforEstrace vaginal cream
Upsides
  • Provera (Medroxyprogesterone) can be used to treat multiple hormone problems in women.
  • After menopause, taking estrogen raises your risk of uterine cancer. However, taking progesterone, like in Provera (Medroxyprogesterone), along with estrogen gives you the positive effects of estrogen, but also prevents it from damaging your uterus.
  • Women taking an estrogen/progestin combination medications have a lower risk of uterine cancer.
  • Side-effects are limited compared to estrogen pill since application is localized to the vagina only.
Downsides
  • You can't take Provera (Medroxyprogesterone) if you've had a hysterectomy (your uterus removed). You also can't take it if you're pregnant or breastfeeding, have unusual vaginal bleeding, or have a history of blood clots, certain kinds of cancer, stroke, heart attack, liver problems, or bleeding problems.
  • Method of application can be difficult or uncomfortable compared to a pill that is taken by mouth.
  • It is not effective for hot flashes.
  • The cream is not compatible with certain birth control methods. It can weaken latex (rubber) condoms, cervical caps, and diaphrams so avoid use within 72 hours after a dose.
  • The applicator can be source of infection if not kept clean.
  • Available as a brand name product only.
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Used for
  • Amenorrhea
  • Abnormal uterine bleeding
  • Prevention of uterine cancer in women taking estrogen
  • Endometriosis
  • Premenstrual syndrome
  • Breast cancer
  • Uterine cancer
  • Pelvic congestion syndrome
  • Birth control (male)
  • Hirsutism
  • Loss of appetite
  • Osteoporosis
  • Renal cell carcinoma
  • Vaginal dryness and inflammation
Dosage forms
  • Pill
  • Cream
Price
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Reviews
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15 reviews so far
60%
saidit'sworth it
73%
saiditworked well
47%
saidit'sa big hassle

Have you used Estrace vaginal cream (Estradiol vaginal cream)?

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Side effects
The Provera (Medroxyprogesterone) FDA package insert doesn’t have numbers about how common side effects are.
The Estrace vaginal cream (Estradiol vaginal cream) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Breast cancer
    • Personal or family history of breast cancer
  • Ovarian cancer
    • Family history of ovarian cancer
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Hypertension
    • Diabetes
    • High cholesterol
    • Systemic lupus erythematosus (SLE)
  • Depression
    • History of depression
  • Liver problems
    • History of liver problems
  • Harm to fetus
    • Women of childbearing age
See more detailed risks and warnings
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen for more than one year
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Inflammation of pancreas
    • High levels of triglycerides
See more detailed risks and warnings