Compare Provera vs. Estring

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Regulates your menstrual cycle and supplements estrogen treatments for menopause.

Provera (Medroxyprogesterone) works well to regulate your menstrual cycle and stop irregular bleeding. It also protects the uterus from estrogen's harmful effects.

Relieves vaginal dryness due to menopause.

Estring (estradiol vaginal ring) is more convenient than other forms of estrogen therapy since you only have to replace it every 3 months, but it needs to be inserted directly into the vagina.

3.3/ 5 average rating with 56 reviewsforEstring
  • Provera (Medroxyprogesterone) can be used to treat multiple hormone problems in women.
  • After menopause, taking estrogen raises your risk of uterine cancer. However, taking progesterone, like in Provera (Medroxyprogesterone), along with estrogen gives you the positive effects of estrogen, but also prevents it from damaging your uterus.
  • Women taking an estrogen/progestin combination medications have a lower risk of uterine cancer.
  • Many women find Estring (estradiol vaginal ring) more comfortable to use and easier to apply than creams or gels.
  • Estring (estradiol vaginal ring) may be more convenient since it is dosed once every 3 months compared to alternatives that need to taken daily or twice weekly.
  • Works directly at the site of application and safer than oral estrogen pills.
  • You can't take Provera (Medroxyprogesterone) if you've had a hysterectomy (your uterus removed). You also can't take it if you're pregnant or breastfeeding, have unusual vaginal bleeding, or have a history of blood clots, certain kinds of cancer, stroke, heart attack, liver problems, or bleeding problems.
  • Estring (estradiol vaginal ring) may not be the best option if you have a narrow vagina or frequent vaginal infections.
  • The ring can fall out without you noticing.
  • Estring (estradiol vaginal ring) is only available as brand name, so can be expensive.
  • Estring (estradiol vaginal ring) All estrogen therapies increase your risk for uterine cancer, heart problems, and blood clots.
Used for
  • Amenorrhea
  • Abnormal uterine bleeding
  • Prevention of uterine cancer in women taking estrogen
  • Endometriosis
  • Premenstrual syndrome
  • Breast cancer
  • Uterine cancer
  • Pelvic congestion syndrome
  • Birth control (male)
  • Hirsutism
  • Loss of appetite
  • Osteoporosis
  • Renal cell carcinoma
  • Vaginal dryness and inflammation
Dosage forms
  • Pill
  • Vaginal ring
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Side effects
The Provera (Medroxyprogesterone) FDA package insert doesn’t have numbers about how common side effects are.
20possible side effects
  • Headache
  • Vaginal discharge
  • Back pain
  • Yeast infection
  • Upper airway infection
  • Vaginal inflammation
  • Vaginal discomfort/pain
  • Arthritis
  • Trouble sleeping
  • Stomach pain
  • Sinus infection
  • Vaginal bleeding
  • Bacterial growth in the genitals
  • Joint pain
  • Nausea
  • Flu-like symptoms
  • Bone pain
  • Bladder infection
  • Hot flashes
  • Stress
See more detailed side effects
Risks and risk factors
  • Breast cancer
    • Personal or family history of breast cancer
  • Ovarian cancer
    • Family history of ovarian cancer
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Hypertension
    • Diabetes
    • High cholesterol
    • Systemic lupus erythematosus (SLE)
  • Depression
    • History of depression
  • Liver problems
    • History of liver problems
  • Harm to fetus
    • Women of childbearing age
See more detailed risks and warnings
  • Uterine cancer
    • Using estrogen for more than one year
    • Higher dose of estrogen
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen and progestin for more than one year
  • Blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Inflammation of pancreas (pancreatitis)
    • High levels of triglycerides
See more detailed risks and warnings