Compare Provigil vs. Dexedrine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Provigil (modafinil)

Prescription only
Improves alertness.

Provigil (modafinil) is effective in improving alertness, but it interacts with some medicines and shouldn't be used long-term.

4.2/ 5 average rating with 28 reviewsforProvigil
Treats attention deficit disorder.

Dexedrine (dextroamphetamine) is an effective medicine for treatment of ADHD, but often abused for recreational purposes.

4.3/ 5 average rating with 28 reviewsforDexedrine
Upsides
  • Provigil (modafinil) is a nonstimulant medication that improves alertness.
  • Provigil (modafinil) is available in a cheaper, generic version.
  • Provigil (modafinil) is good at decreasing excessive sleepiness in shift work sleep disorder.
  • If you need to sleep in the daytime, this medication won't effect you.
  • Recommended as a first-choice treatment of ADHD.
  • Available as generic version.
  • For more flexible dosing schedule, Dexedrine (dextroamphetamine) is available in short and long formulations.
  • If you have difficulty swallowing pills, Dexedrine (dextroamphetamine) is available as a liquid.
Downsides
  • Provigil (modafinil) can be habit forming, so it shouldn't be used for long-term treatment.
  • Provigil (modafinil) is not a good choice if you have liver problems.
  • May not be a good option if you are taking hormonal contraception like birth control pills.
  • Taking Dexedrine (dextroamphetamine) can decrease your appetite.
  • If taken late in the day, Dexedrine (dextroamphetamine) can cause insomnia.
  • People who take high doses of Dexedrine (dextroamphetamine) are more likely to have anxiety, restlessness, or irritability.
  • Requires a new prescription from your doctor every month.
  • Not a good option if you have a history of seizures.
  • Can be habit-forming so make sure you use it only as prescribed.
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Used for
Dosage forms
  • Pill
  • Pill
  • Extended release
  • Liquid
Price
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Reviews
28 reviews so far
82%
saidit'sworth it
71%
saiditworked well
4%
saidit'sa big hassle

Have you used Provigil (modafinil)?

Leave a review
28 reviews so far
89%
saidit'sworth it
79%
saiditworked well
21%
saidit'sa big hassle

Have you used Dexedrine (dextroamphetamine)?

Leave a review
Side effects
25possible side effects
  • Headache
    34%
  • Nausea
    11%
  • Nervousness
    7%
  • Stuffy nose
    7%
  • Back pain
    6%
  • Diarrhea
    6%
  • Indigestion
    5%
  • Difficulty sleeping
    5%
  • Anxiety
    5%
  • Dizziness
    5%
  • Flu symptoms
    4%
  • Dry mouth
    4%
  • Loss of appetite
    4%
  • Throat inflammation
    4%
  • Chest pain
    3%
  • High blood pressure
    3%
  • Fast heart beat
    2%
  • Palpitation
    2%
  • Dilation of blood vessels
    2%
  • Constipation
    2%
  • Abnormal liver function
    2%
  • Depression
    2%
  • Burning/tingling sensation
    2%
  • Drowsiness
    2%
  • Lung disorder
    2%
See more detailed side effects
The Dexedrine (dextroamphetamine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Serious allergic reactions
    • Allergy to Provigil (modafinil)
  • Heart problems
    • History of heart problems
  • Increased side effects
    • Current kidney problems
    • Current liver problems
  • Driving impairment
    • Taking with alcohol or drugs
See more detailed risks and warnings
  • Abuse and dependence
    • History of drug abuse
  • Serious or life-threatening heart problems
    • History of heart problems
  • Aggressive behavior and psychosis
    • History of psychotic episodes
    • History of bipolar disorder
  • Long-term growth suppression
    • Children
  • Seizures
    • History of seizures
  • Serotonin Syndrome (rare, life-threatening)
    • Using other medicines that increase serotonin levels in the brain
See more detailed risks and warnings