Compare Provigil vs. Marinol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Provigil (modafinil)

Prescription only

Marinol (dronabinol)

Prescription only
Improves alertness.

Provigil (modafinil) is effective in improving alertness, but it interacts with some medicines and shouldn't be used long-term.

4.2/ 5 average rating with 28 reviewsforProvigil
Treats appetite loss and nausea.

Marinol (dronabinol) can help with appetite stimulation and nausea/vomiting; however, there are other medicines available that might work better and have less side effects.

Upsides
  • Provigil (modafinil) is a nonstimulant medication that improves alertness.
  • Provigil (modafinil) is available in a cheaper, generic version.
  • Provigil (modafinil) is good at decreasing excessive sleepiness in shift work sleep disorder.
  • If you need to sleep in the daytime, this medication won't effect you.
  • The appetite stimulating effects of Marinol (dronabinol) can last up to 5 months.
  • Marinol (dronabinol) is available in cheaper, generic form.
  • Can also improve mood and body weight in some people.
Downsides
  • Provigil (modafinil) can be habit forming, so it shouldn't be used for long-term treatment.
  • Provigil (modafinil) is not a good choice if you have liver problems.
  • May not be a good option if you are taking hormonal contraception like birth control pills.
  • Adults age 65 or older might be more sensitive to the side effects of Marinol (dronabinol), especially mental/physical ability impairment, psychological changes, and blood pressure changes.
  • This medicine might actually worsen nausea/vomiting or cause stomach pain. If this happens, your doctor can change your dose or stop the medicine.
  • Can cause dry mouth and effect your dental health, so maintain good dental hygiene.
  • Can help with appetite stimulation, but does not stimulate weight gain.
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Used for
  • Treatment of appetite and weight loss in people with AIDS
  • Treatment of nausea and vomiting from chemotherapy
  • Treatment and prevention of postoperative nausea and vomiting
Dosage forms
  • Pill
  • Pill
Price
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Reviews
28 reviews so far
82%
saidit'sworth it
71%
saiditworked well
4%
saidit'sa big hassle

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Side effects
25possible side effects
  • Headache
    34%
  • Nausea
    11%
  • Nervousness
    7%
  • Stuffy nose
    7%
  • Back pain
    6%
  • Diarrhea
    6%
  • Indigestion
    5%
  • Difficulty sleeping
    5%
  • Anxiety
    5%
  • Dizziness
    5%
  • Flu symptoms
    4%
  • Dry mouth
    4%
  • Loss of appetite
    4%
  • Throat inflammation
    4%
  • Chest pain
    3%
  • High blood pressure
    3%
  • Fast heart beat
    2%
  • Palpitation
    2%
  • Dilation of blood vessels
    2%
  • Constipation
    2%
  • Abnormal liver function
    2%
  • Depression
    2%
  • Burning/tingling sensation
    2%
  • Drowsiness
    2%
  • Lung disorder
    2%
See more detailed side effects
The Marinol (dronabinol) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Serious allergic reactions
    • Allergy to Provigil (modafinil)
  • Heart problems
    • History of heart problems
  • Increased side effects
    • Current kidney problems
    • Current liver problems
  • Driving impairment
    • Taking with alcohol or drugs
See more detailed risks and warnings
  • Impairment of mental or physical abilities
    • Taking other medicines that cause drowsiness, dizziness, or confusion
  • Seizures
    • History of seizures
  • Heart and blood vessel changes
    • History of heart problems
    • Used with other medicines that have similar effects on the heart and blood vessels
  • Substance abuse
    • History of subastance abuse
    • History of alcohol dependence
  • Hypersensitivity (allergic) reaction
  • Mood and behavior changes
    • History of mental illness
See more detailed risks and warnings