Compare Prozac vs. Pristiq
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Improves mood and helps you relax.
Prozac (fluoxetine) is good for treating depression and anxiety. It's more energizing than other antidepressants, so it may not be the best choice for people who have trouble sleeping.
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3.5/ 5 average rating with 1319 reviewsforProzac
Improves mood.
Pristiq (desvenlafaxine) is an effective medicine for treating depression, but it is more expensive than many other medicines that work just like it.
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3.5/ 5 average rating with 196 reviewsforPristiq
Upsides
- Effectively treats a variety of mental health conditions such as depression, OCD, and panic disorder.
- It's more energizing than other antidepressants, so it's good for people who have low energy.
- Might be a good option for treating children with depression and/or OCD.
- Doesn't have effects on the heart unlike other antidepressants so it may be a better treatment choice for older people.
- Can cause a significant amount of weight loss which is an added benefit for those who are overweight or obese.
- You only need to take Pristiq (desvenlafaxine) once a day.
- May be taken with or without food.
- Less sedating than other anti-depressants.
Downsides
- Takes at least 1 to 2 weeks to kick in and can take up to 12 weeks for maximum effect. Prozac (fluoxetine) tends to take more time to start working compared to similar alternatives.
- Can lower your sex drive.
- Can increase the risk of suicidal thoughts and/or behavior in those age 24 or younger.
- You may need to try out several different antidepressants before you find the one that works for you.
- Like most anti-depressants, full effect on mood takes up to 12 weeks.
- Can increase the risk of suicidal thoughts and/or behavior in yound adults 24 years and younger.
- Can affect your sex drive and ability to get an erection.
Used for
Dosage forms
- Pill
- Delayed-release pill
- Liquid
- Extended-release pill
Price
No pricing information available
Lowest price
$24.13
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Reviews
1319 reviews so far
62%
saidit'sworth it
40%
saiditworked well
16%
saidit'sa big hassle
Have you used Prozac (fluoxetine)?
Leave a review196 reviews so far
53%
saidit'sworth it
49%
saiditworked well
23%
saidit'sa big hassle
Have you used Pristiq (desvenlafaxine)?
Leave a reviewSide effects
22possible side effects
- Inability to sleep33%
- Nausea28%
- Lack of energy21%
- Anxiety15%
- Sleepiness13%
- Tremor13%
- Nervousness11%
- Yawn11%
- Indigestion10%
- Sore throat10%
- Dry mouth9%
- Flu syndrome8%
- Diarrhea8%
- Loss of appetite8%
- Sweating8%
- Impotence7%
- Abnormal ejaculation7%
- Sinus infection6%
- Lower sex drive5%
- Abnormal dreams5%
- Rash4%
- Widening of blood vessels2%
17possible side effects
- Nausea22%
- Dizziness13%
- Dry mouth11%
- Excessive sweating10%
- Constipation9%
- Inability to sleep9%
- Tiredness7%
- Decreased appetite5%
- Drowsiness4%
- Vomiting3%
- Anxiety3%
- Blurry vision3%
- Tremor2%
- Abnormal dreams2%
- Dilated pupils2%
- Vertigo2%
- Ringing in ears2%
Risks and risk factors
- Suicidal thoughts or behavior
- Age 24 or younger
- Serotonin syndrome
- Antidepressants
- Lithium
- Ultram
- Imitrex
- Remeron
- Lexapro
- Dilaudid
- St. John's Wort
- Skin rash
- Weight loss
- People with an eating disorder
- Increased bleeding risk
- Taking NSAIDS or blood-thinning drugs
- Abnormal heart rhythm
- People with heart rhythm problems or a family history of them
- Low potassium level
- Low magnesium level
- Recent heart attack
- Using other drugs that affect heart rhythm
- Overdose
- People with liver problems
- Suicidal thoughts or behavior
- Age 24 or younger
- Serotonin syndrome
- Taking other medicines that also increase serotonin activity: Antidepressants (SSRIs, SNRIs, TCAs)
- lithium
- tramadol
- Imitrex
- Remeron
- Lexapro
- Dilaudid
- Increased blood pressure
- People with a history of high blood pressure or other heart conditions
- Increased bleeding risk
- Taking NSAIDS, blood thinners, or aspirin
- Low sodium levels in blood
- Older people
- Taking diuretics
- Stopping Pristiq (desvenlafaxine) too quickly
- Taking the medicine for a long time
- Stopping Pristiq (desvenlafaxine) too quickly