Compare Prozac vs. Valium

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Prozac (fluoxetine)

Prescription only

Valium (diazepam)

Prescription only
Improves mood and helps you relax.

Prozac (fluoxetine) is good for treating depression and anxiety. It's more energizing than other antidepressants, so it may not be the best choice for people who have trouble sleeping.

3.5/ 5 average rating with 1319 reviewsforProzac
Helps you relax.

Valium (diazepam) is effective for occasional or short-term use for anxiety and muscle spasm. Compared to similar drugs, Valium (diazepam) acts very quickly but can have interactions with other medicines.

3.8/ 5 average rating with 976 reviewsforValium
Upsides
  • Effectively treats a variety of mental health conditions such as depression, OCD, and panic disorder.
  • It's more energizing than other antidepressants, so it's good for people who have low energy.
  • Might be a good option for treating children with depression and/or OCD.
  • Doesn't have effects on the heart unlike other antidepressants so it may be a better treatment choice for older people.
  • Can cause a significant amount of weight loss which is an added benefit for those who are overweight or obese.
  • Valium (diazepam) effectively relieves anxiety and muscle spasms.
  • Valium (diazepam) has less severe withdrawal symptoms compared to other similar drugs.
  • Works very quickly.
  • Available in generic.
Downsides
  • Takes at least 1 to 2 weeks to kick in and can take up to 12 weeks for maximum effect. Prozac (fluoxetine) tends to take more time to start working compared to similar alternatives.
  • Can lower your sex drive.
  • Can increase the risk of suicidal thoughts and/or behavior in those age 24 or younger.
  • You may need to try out several different antidepressants before you find the one that works for you.
  • Use of Valium (diazepam) can cause memory problems, drowsiness, dizziness, and confusion.
  • Valium (diazepam) can be habit-forming, so it's not typically used for long-term treatment.
  • Most people find that their body will get used to Valium (diazepam) levels and they may need higher doses over time to achieve the same effect.
  • People with severe liver problems should not take Valium (diazepam). Several drugs can also interfere with how Valium (diazepam) works.
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Used for
Dosage forms
  • Pill
  • Delayed-release pill
  • Liquid
  • Pill
  • Liquid
Price
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Reviews
1319 reviews so far
62%
saidit'sworth it
40%
saiditworked well
16%
saidit'sa big hassle

Have you used Prozac (fluoxetine)?

Leave a review
976 reviews so far
70%
saidit'sworth it
53%
saiditworked well
15%
saidit'sa big hassle

Have you used Valium (diazepam)?

Leave a review
Side effects
22possible side effects
  • Inability to sleep
    33%
  • Nausea
    28%
  • Lack of energy
    21%
  • Anxiety
    15%
  • Sleepiness
    13%
  • Tremor
    13%
  • Nervousness
    11%
  • Yawn
    11%
  • Indigestion
    10%
  • Sore throat
    10%
  • Dry mouth
    9%
  • Flu syndrome
    8%
  • Diarrhea
    8%
  • Loss of appetite
    8%
  • Sweating
    8%
  • Impotence
    7%
  • Abnormal ejaculation
    7%
  • Sinus infection
    6%
  • Lower sex drive
    5%
  • Abnormal dreams
    5%
  • Rash
    4%
  • Widening of blood vessels
    2%
See more detailed side effects
The Valium (diazepam) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Suicidal thoughts or behavior
    • Age 24 or younger
  • Serotonin syndrome
    • Antidepressants
    • Lithium
    • Ultram
    • Imitrex
    • Remeron
    • Lexapro
    • Dilaudid
    • St. John's Wort
  • Skin rash
  • Weight loss
    • People with an eating disorder
  • Increased bleeding risk
    • Taking NSAIDS or blood-thinning drugs
  • Abnormal heart rhythm
    • People with heart rhythm problems or a family history of them
    • Low potassium level
    • Low magnesium level
    • Recent heart attack
    • Using other drugs that affect heart rhythm
    • Overdose
    • People with liver problems
See more detailed risks and warnings
  • Decreased breathing from use with opioids
    • Taking Valium (diazepam) with opioids, drugs or alcohol
    • Using Valium (diazepam) for a longer duration and at high doses
  • Dependence and withdrawal
    • History of substance abuse
    • Taking with alcohol or drugs
    • Taking long-term
    • Taking a higher dose
    • Stopping Valium (diazepam) suddenly
  • Driving impairment
    • Alcohol use with Valium (diazepam)
    • Taking other medicines that make you less alert
  • Drug interactions
    • Current liver problems
    • Taking Tagamet, ketoconazole, Prozac, Prilosec
See more detailed risks and warnings