Compare Rapamune vs. Afinitor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Rapamune (sirolimus)

Prescription only

Afinitor (everolimus)

Prescription only
Prevents rejection of a transplanted organ.

Rapamune (sirolimus) is a reliable medicine that prevents rejection of an organ transplant but requires consistent monitoring.

Treats different types of cancer.

Treats different types of cancer, but can cause uncomfortable side effects.

Upsides
  • Rapamune (sirolimus) is good at preventing organ rejection.
  • Causes less harm to the kidneys with long-term use than similar medicines.
  • Fewer effects on blood sugar and blood pressure compared to other immunosuppressants.
  • Conveniently taken once daily.
  • Afinitor (everolimus) comes as a pill rather than an injection, unlike some other cancer drugs.
Downsides
  • You’ll need regular blood tests while taking Rapamune (sirolimus), especially when you first start the medicine.
  • Can cause high lipids (fats like cholesterol and triglycerides), especially with lifelong use. You might need to take other medicines to control your lipids while on Rapamune (sirolimus).
  • Raises your risk of infection and certain cancers.
  • Afinitor (everolimus) has many uncomfortable and potentially intolerable side effects.
  • You may be more prone to infections and take longer to recover from a wound while taking Afinitor (everolimus).
  • Some prescription medications, vitamins and supplements can interfere with how Afinitor (everolimus) works.
  • Afinitor (everolimus) might not be the best option if you have liver problems.
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Used for
  • Prevention of kidney transplant rejection
  • Lymphangioleiomyomatosis
Dosage forms
  • Pill
  • Liquid
  • Pill
Price
Lowest price
$14450.00
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Reviews
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Side effects
17possible side effects
  • Swelling in arms and legs
    54%
  • High triglycerides
    45%
  • High blood pressure
    45%
  • High cholesterol
    43%
  • Higher blood creatinine (marker of poorer kidney function)
    39%
  • Constipation
    36%
  • Headache
    34%
  • Stomach pain
    28%
  • Urinary tract infection
    26%
  • Diarrhea
    25%
  • Nausea
    25%
  • Joint pain
    25%
  • Fever
    23%
  • Low red blood cells
    23%
  • Acne
    22%
  • Low white blood cells
    14%
  • Rash
    10%
See more detailed side effects
34possible side effects
  • Mouth sores
    70%
  • Rash
    59%
  • Diarrhea
    50%
  • Tiredness
    45%
  • Swelling
    39%
  • Stomach pain
    36%
  • Nausea
    32%
  • Fever
    31%
  • Decreased appetite
    30%
  • Headache
    30%
  • Vomiting
    28%
  • Weight loss
    28%
  • Common cold
    25%
  • Cough
    25%
  • Nosebleed
    22%
  • Nail disorder
    22%
  • Itchy skin
    21%
  • Difficulty breathing
    20%
  • Weakness
    19%
  • Decreased taste sensitivity
    19%
  • Lung inflammation
    17%
  • Urinary tract infection
    16%
  • Joint pain
    15%
  • Back pain
    15%
  • Constipation
    14%
  • Pain in extremity
    14%
  • Difficulty sleeping
    14%
  • Dry skin
    13%
  • High blood pressure
    13%
  • Dizziness
    12%
  • Dry mouth
    11%
  • Throat pain
    11%
  • Diabetes
    10%
  • Muscle spasms
    10%
See more detailed side effects
Risks and risk factors
  • Health problems in people with liver and lung transplants
  • Cancer
    • Taking Rapamune (sirolimus) for a long time
    • Long exposure to sunlight
    • UV light
  • Serious infections
    • Taking other immunosuppressants
    • Age 60 or older
    • Weak immune system
  • High blood lipids (cholesterol and triglycerides)
    • History of high cholesterol
    • History of high triglycerides
  • Drug interactions
    • Taking multiple medicines
See more detailed risks and warnings
  • Infection
  • Kidney disease
  • Lung problems
  • Reaction to live vaccines
  • Swelling of the airways or tongue
    • Taking ACE inhibitor
  • Mouth ulcers
See more detailed risks and warnings