Compare Reclast vs. Evista

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Reclast (zoledronate)

Prescription only

Evista (raloxifene)

Prescription only
Prevents bone loss.

Reclast (zoledronate) is a good choice for osteoporosis if you aren't able to take bisphosphonates by mouth. It is available as a generic, but you have to see a doctor to get each dose.

3.1/ 5 average rating with 39 reviewsforReclast
Prevents bone loss and lowers your risk of invasive breast cancer.

Evista (raloxifene) helps to reduce bone loss and lower the risk of breast cancer in post-menopausal women, but it can cause blood clots.

Upsides
  • Available in generic.
  • Depending on what you're using it for, you may only need to take it as a one-time dose, or every 1 to 2 years.
  • Evista (raloxifene) is a good choice for prevention of bone loss for postmenopausal women. Evista (raloxifene) can also reduce your risk for invasive breast cancer.
  • Unlike bisphosphonates, Evista (raloxifene) is easier on your stomach.
  • Although Evista (raloxifene) acts like estrogen, it doesn't increase the chances of uterine or breast cancer.
  • If you are having hot flashes, Evista (raloxifene) may help relieve them, unlike some alternatives.
Downsides
  • You have to go to your doctor's office or an infusion center to get each dose by IV infusion.
  • It can't be used if you have really poor kidney function.
  • Joint pain and muscle pain are common side effects after the infusion.
  • Evista (raloxifene) can cause side effects similar to estrogen such as clots and hot flashes, which doesn't happen with bisphosphonate alternatives like Fosamax (alendronate).
  • Premenopausal women cannot take Evista (raloxifene) for breast cancer prevention.
  • It is not the first choice treatment for osteoporosis unless you cannot take bisphosphonates.
  • Your doctor may ask you to take this medicine for years to prevent bone loss.
  • If you are on a blood-thinner called warfarin, you may need to do a blood test before starting this medicine.
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Used for
  • Post-menopausal osteoporosis
  • Breast cancer prevention
Dosage forms
  • Injection
  • Pill
Price
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Reviews
39 reviews so far
28%
saidit'sworth it
28%
saiditworked well
36%
saidit'sa big hassle

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Side effects
17possible side effects
  • Muscle aches
    20%
  • Fatigue
    18%
  • Headache
    15%
  • Muscle pain
    12%
  • Pain
    12%
  • Chills
    10%
  • Influenza-like illness
    9%
  • Stomach pain
    8%
  • Shortness of breath
    7%
  • Feeling unwell
    7%
  • Musculoskeletal stiffness
    5%
  • Lack of energy
    3%
  • Atrial fibrillation
    3%
  • Palpitations
    3%
  • Excessive sweating
    3%
  • Eye pain
    2%
  • Lower kidney function
    2%
See more detailed side effects
45possible side effects
  • Hot flashes
    25%
  • Joint pain
    16%
  • Flu-like symptoms
    15%
  • Infection
    11%
  • Stuffy nose
    10%
  • Difficulty breathing
    10%
  • Sinus infection
    10%
  • Headache
    9%
  • Increased cough
    9%
  • Nausea
    9%
  • Weight gain
    9%
  • Muscle pain
    8%
  • Sore throat
    8%
  • Leg cramps
    7%
  • Diarrhea
    7%
  • Stomach pain
    7%
  • Indigestion
    6%
  • Depression
    6%
  • Difficulty sleeping
    6%
  • Rash
    6%
  • Vaginal bleeding
    6%
  • Vomiting
    5%
  • Swelling
    5%
  • Fever
    4%
  • Tendon disorder
    4%
  • Vertigo
    4%
  • Chest pain
    4%
  • Arthritis
    4%
  • Bladder infection
    4%
  • Breast Pain
    4%
  • Sweating
    3%
  • Uterine disorder
    3%
  • Urinary tract disorder
    3%
  • Flatulence
    3%
  • Stomach and intestinal disorders
    3%
  • Stomach flu
    3%
  • Swelling in arms or legs
    3%
  • Pneumonia
    3%
  • Vaginal discharge
    3%
  • Endometrial disorder
    3%
  • Fainting
    2%
  • Stabbing nerve pain
    2%
  • Pink eye
    2%
  • Migraine
    2%
  • Inflamed vocal cords
    2%
See more detailed side effects
Risks and risk factors
  • Pain in the bones and muscles
  • Problems in the jawbone
    • Oral or dental surgery
    • Cancer
    • Poor oral hygiene
  • Leg bone fractures
  • Low calcium in the blood
    • Low parathyroid hormone
    • History of thyroid surgery
    • Problems with calcium absorption
  • Kidney injury
    • Kidney disease
    • Taking a water pill
    • Dehydrated
    • Elderly
See more detailed risks and warnings
  • Increased risk of blood clots and stroke
    • History of blood clots or stroke
    • History of heart disease
    • Long-distance travel
    • Major surgery
    • Prolonged immobilization
    • Smoking
    • Heart failure
    • High blood pressure
  • Premenopausal women
  • Breast cancer
    • History of breast cancer
  • Overdose
    • History of liver disease
    • History of kidney disease
    • Taking estrogen
See more detailed risks and warnings