Compare Reclast vs. Evista

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Reclast (zoledronate)

Prescription only

Evista (Raloxifene)

Prescription only
Prevents bone loss.

Reclast (zoledronate) is a good choice for osteoporosis if you aren't able to take bisphosphonates by mouth. It is available as a generic, but you have to see a doctor to get each dose.

3.1/ 5 average rating with 39 reviewsforReclast
Prevents bone loss and lowers your risk of breast cancer.

Evista (Raloxifene) is effective at reducing bone loss and lowering the risk of breast cancer in postmenopausal women, but does carry the risk of blood clots.

Upsides
  • Available in generic.
  • Depending on what you're using it for, you may only need to take it as a one-time dose, or every 1 to 2 years.
  • Evista (Raloxifene) doesn’t affect the breast or uterus the same way that estrogen does, so the risk of cancer is much lower.
  • Taking Evista (Raloxifene) with calcium and vitamin D improves spine and hip bone health and lowers the risk of fractures.
  • Lowers total cholesterol and low-density lipoprotein (LDL) cholesterol (the bad cholesterol).
Downsides
  • You have to go to your doctor's office or an infusion center to get each dose by IV infusion.
  • It can't be used if you have really poor kidney function.
  • Joint pain and muscle pain are common side effects after the infusion.
  • Can only take Evista (Raloxifene) once you’re in menopause. You can't take it if you're pregnant or breastfeeding.
  • Evista (Raloxifene) isn’t as effective as tamoxifen at lowering the risk of invasive breast cancer.
  • Shouldn’t take it with any other forms of estrogen (pills, patches, or injection).
  • It doesn’t increase bone strength as much as estrogen does and isn’t effective for treating hot flashes.
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Used for
Dosage forms
  • Injection
  • Pill
Price
No pricing information available
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Reviews
39 reviews so far
28%
saidit'sworth it
28%
saiditworked well
36%
saidit'sa big hassle

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Side effects
17possible side effects
  • Muscle aches
    20%
  • Fatigue
    18%
  • Headache
    15%
  • Muscle pain
    12%
  • Pain
    12%
  • Chills
    10%
  • Influenza-like illness
    9%
  • Stomach pain
    8%
  • Shortness of breath
    7%
  • Feeling unwell
    7%
  • Musculoskeletal stiffness
    5%
  • Lack of energy
    3%
  • Atrial fibrillation
    3%
  • Palpitations
    3%
  • Excessive sweating
    3%
  • Eye pain
    2%
  • Lower kidney function
    2%
See more detailed side effects
6possible side effects
  • Any side effect
    25%
  • Peripheral edema
    14%
  • Muscle spasms/leg cramps
    12%
  • Hot Flashes
    8%
  • Cholelithiasis
    3%
  • Venous thromboembolic events
    2%
See more detailed side effects
Risks and risk factors
  • Pain in the bones and muscles
  • Problems in the jawbone
    • Oral or dental surgery
    • Cancer
    • Poor oral hygiene
  • Leg bone fractures
  • Low calcium in the blood
    • Low parathyroid hormone
    • History of thyroid surgery
    • Problems with calcium absorption
  • Kidney injury
    • Kidney disease
    • Taking a water pill
    • Dehydrated
    • Elderly
See more detailed risks and warnings
  • Increased risk of stroke
    • History of stroke
    • Heart and blood vessel problems
    • History of mini stroke (TIA)
    • Atrial fibrillation
    • Smoking
    • High blood pressure
  • Increased risk of blood clots
  • Elevated triglycerides (fats in blood)
    • History of high triglycerides
  • Worsening kidney or liver function
See more detailed risks and warnings