Compare Reclast vs. Nolvadex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Reclast (zoledronate)

Prescription only

Nolvadex (Tamoxifen)

Prescription only
Prevents bone loss.

Reclast (zoledronate) is a good choice for osteoporosis if you aren't able to take bisphosphonates by mouth. It is available as a generic, but you have to see a doctor to get each dose.

3.1/ 5 average rating with 39 reviewsforReclast
Lowers risk of and treats breast cancer.

Nolvadex (Tamoxifen) is an effective, first-line option for certain types of breast cancers, but it has many severe side effects and needs a lot of monitoring.

Upsides
  • Available in generic.
  • Depending on what you're using it for, you may only need to take it as a one-time dose, or every 1 to 2 years.
  • In studies, postmenopausal women who were at high risk for breast cancer took Nolvadex (Tamoxifen) for 5 years and lowered their risk by about 50%.
  • Nolvadex (Tamoxifen) is the only medicine approved to lower risk of breast cancer regardless of menopausal status. Other medicines are approved only for postmenopausal women.
  • Effective in treating metastatic breast cancer in men and women.
  • Available in both tablets and a sugar-free solution.
Downsides
  • You have to go to your doctor's office or an infusion center to get each dose by IV infusion.
  • It can't be used if you have really poor kidney function.
  • Joint pain and muscle pain are common side effects after the infusion.
  • If you're taking Nolvadex (Tamoxifen) to lower your risk for breast cancer, it can raise your risk of having a stroke or getting a blood clot, especially if you have a history of blood clots or you're currently taking a blood thinner, like warfarin. Tell your doctor about any health conditions before you start taking Nolvadex (Tamoxifen).
  • Can raise the risk of fractures in premenopausal women.
  • There are many drug interactions, including antidepressants and other chemotherapy (anti-cancer) medicines. Talk to your doctor or pharmacist before making any changes.
  • Requires regular blood tests and doctor exams to monitor for side effects.
  • Not the best choice if you have eye or liver problems.
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Used for
Dosage forms
  • Injection
  • Pill
  • Liquid
Price
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Reviews
39 reviews so far
28%
saidit'sworth it
28%
saiditworked well
36%
saidit'sa big hassle

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Side effects
17possible side effects
  • Muscle aches
    20%
  • Fatigue
    18%
  • Headache
    15%
  • Muscle pain
    12%
  • Pain
    12%
  • Chills
    10%
  • Influenza-like illness
    9%
  • Stomach pain
    8%
  • Shortness of breath
    7%
  • Feeling unwell
    7%
  • Musculoskeletal stiffness
    5%
  • Lack of energy
    3%
  • Atrial fibrillation
    3%
  • Palpitations
    3%
  • Excessive sweating
    3%
  • Eye pain
    2%
  • Lower kidney function
    2%
See more detailed side effects
21possible side effects
  • Hot Flashes
    65%
  • Flush
    33%
  • Fluid Retention
    32%
  • Vaginal Discharge
    30%
  • Nausea
    26%
  • Irregular Menses
    25%
  • Weight Loss (>5%)
    23%
  • Skin Changes
    19%
  • Amenorrhea
    16%
  • Altered Menses
    13%
  • Oligomenorrhea
    9%
  • Bone Pain
    6%
  • Menstrual Disorder
    6%
  • Thrombocytopenia
    5%
  • Cough/Coughing
    4%
  • Edema
    4%
  • Fatigue
    4%
  • Muscoloskeletal Pain
    3%
  • Pain
    3%
  • Ovarian Cyst(s)
    3%
  • Depression
    2%
See more detailed side effects
Risks and risk factors
  • Pain in the bones and muscles
  • Problems in the jawbone
    • Oral or dental surgery
    • Cancer
    • Poor oral hygiene
  • Leg bone fractures
  • Low calcium in the blood
    • Low parathyroid hormone
    • History of thyroid surgery
    • Problems with calcium absorption
  • Kidney injury
    • Kidney disease
    • Taking a water pill
    • Dehydrated
    • Elderly
See more detailed risks and warnings
  • Serious and life-threatening events
  • Harm to fetus
    • Women of childbearing age
  • Increased risk of vision changes
  • Worsening liver function
    • Current liver problems
  • Blood disorders
See more detailed risks and warnings