Compare Reclast vs. Prolia

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Reclast (zoledronate)

Prescription only

Prolia (Denosumab)

Prescription only
Prevents bone loss.

Reclast (zoledronate) is a good choice for osteoporosis if you aren't able to take bisphosphonates by mouth. It is available as a generic, but you have to see a doctor to get each dose.

3.1/ 5 average rating with 39 reviewsforReclast
Prevents bone loss.

Prolia (Denosumab) is an effective and convenient treatment for osteoporosis if other options haven’t worked or aren’t appropriate for you. There’re risks of some rare side effects, so make sure you're following up with your doctor regularly.

3.6/ 5 average rating with 15 reviewsforProlia
Upsides
  • Available in generic.
  • Depending on what you're using it for, you may only need to take it as a one-time dose, or every 1 to 2 years.
  • Prolia (Denosumab) is effective at preventing bone loss, making your bones stronger and lowering your chance of getting a fracture.
  • Only need to get an injection every 6 months, so you don’t have to remember to take something every day.
Downsides
  • You have to go to your doctor's office or an infusion center to get each dose by IV infusion.
  • It can't be used if you have really poor kidney function.
  • Joint pain and muscle pain are common side effects after the infusion.
  • Approved for women only after they’ve reached menopause. Don’t use this if you’re pregnant or planning to become pregnant.
  • Can lower blood calcium levels. You might need to take calcium supplements to prevent this.
  • Not available as a generic.
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Used for
Dosage forms
  • Injection
  • Injection
Price
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Reviews
39 reviews so far
28%
saidit'sworth it
28%
saiditworked well
36%
saidit'sa big hassle

Have you used Reclast (zoledronate)?

Leave a review
15 reviews so far
33%
saidit'sworth it
40%
saiditworked well
27%
saidit'sa big hassle

Have you used Prolia (Denosumab)?

Leave a review
Side effects
17possible side effects
  • Muscle aches
    20%
  • Fatigue
    18%
  • Headache
    15%
  • Muscle pain
    12%
  • Pain
    12%
  • Chills
    10%
  • Influenza-like illness
    9%
  • Stomach pain
    8%
  • Shortness of breath
    7%
  • Feeling unwell
    7%
  • Musculoskeletal stiffness
    5%
  • Lack of energy
    3%
  • Atrial fibrillation
    3%
  • Palpitations
    3%
  • Excessive sweating
    3%
  • Eye pain
    2%
  • Lower kidney function
    2%
See more detailed side effects
27possible side effects
  • Back pain
    35%
  • Pain in extremity
    12%
  • Musculoskeletal pain
    8%
  • Hypercholesterolemia
    7%
  • Cystitis
    6%
  • Vertigo
    5%
  • Edema peripheral
    5%
  • Upper respiratory tract infection
    5%
  • Sciatica
    5%
  • Pneumonia
    4%
  • Bone pain
    4%
  • Anemia
    3%
  • Angina pectoris
    3%
  • Abdominal pain upper
    3%
  • Myalgia
    3%
  • Insomnia
    3%
  • Rash
    3%
  • Atrial fibrillation
    2%
  • Flatulence
    2%
  • Gastroesophageal reflux disease
    2%
  • Asthenia
    2%
  • Pharyngitis
    2%
  • Herpes zoster
    2%
  • Spinal osteoarthritis
    2%
  • Pruritus
    2%
  • Mortality
    2%
  • Adverse events
    2%
See more detailed side effects
Risks and risk factors
  • Pain in the bones and muscles
  • Problems in the jawbone
    • Oral or dental surgery
    • Cancer
    • Poor oral hygiene
  • Leg bone fractures
  • Low calcium in the blood
    • Low parathyroid hormone
    • History of thyroid surgery
    • Problems with calcium absorption
  • Kidney injury
    • Kidney disease
    • Taking a water pill
    • Dehydrated
    • Elderly
See more detailed risks and warnings
  • Leg bone fractures
    • Taking steroids
  • Hypersensitivity (allergic) reactions
  • Low calcium blood levels
    • Kidney problems
    • Not taking calcium supplements
    • Taking other medicines that can lower calcium blood levels
    • History of hypoparathyroidism (low levels of parathyroid hormone)
  • Infection
    • Weak immune system
    • Taking medicines that block your immune system (such as transplant medications or steroids)
  • Problems in the jaw bone
    • Oral or dental surgery
    • Cancer diagnosis
    • Taking steroids or chemotherapy
    • Poor oral hygiene
  • Pain in the bones and muscles
See more detailed risks and warnings