Compare Reclast vs. Prolia
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Prevents bone loss.
Reclast (zoledronate) is a good choice for osteoporosis if you aren't able to take bisphosphonates by mouth. It is available as a generic, but you have to see a doctor to get each dose.
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3.1/ 5 average rating with 39 reviewsforReclast
Prevents bone loss.
Prolia (Denosumab) is an effective and convenient treatment for osteoporosis if other options haven’t worked or aren’t appropriate for you. There’re risks of some rare side effects, so make sure you're following up with your doctor regularly.
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3.6/ 5 average rating with 15 reviewsforProlia
Upsides
- Available in generic.
- Depending on what you're using it for, you may only need to take it as a one-time dose, or every 1 to 2 years.
- Prolia (Denosumab) is effective at preventing bone loss, making your bones stronger and lowering your chance of getting a fracture.
- Only need to get an injection every 6 months, so you don’t have to remember to take something every day.
Downsides
- You have to go to your doctor's office or an infusion center to get each dose by IV infusion.
- It can't be used if you have really poor kidney function.
- Joint pain and muscle pain are common side effects after the infusion.
- Approved for women only after they’ve reached menopause. Don’t use this if you’re pregnant or planning to become pregnant.
- Can lower blood calcium levels. You might need to take calcium supplements to prevent this.
- Not available as a generic.
Used for
Dosage forms
- Injection
- Injection
Price
Lowest price
$34.88
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$2269.30
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Reviews
39 reviews so far
28%
saidit'sworth it
28%
saiditworked well
36%
saidit'sa big hassle
Have you used Reclast (zoledronate)?
Leave a review15 reviews so far
33%
saidit'sworth it
40%
saiditworked well
27%
saidit'sa big hassle
Have you used Prolia (Denosumab)?
Leave a reviewSide effects
17possible side effects
- Muscle aches20%
- Fatigue18%
- Headache15%
- Muscle pain12%
- Pain12%
- Chills10%
- Influenza-like illness9%
- Stomach pain8%
- Shortness of breath7%
- Feeling unwell7%
- Musculoskeletal stiffness5%
- Lack of energy3%
- Atrial fibrillation3%
- Palpitations3%
- Excessive sweating3%
- Eye pain2%
- Lower kidney function2%
27possible side effects
- Back pain35%
- Pain in extremity12%
- Musculoskeletal pain8%
- Hypercholesterolemia7%
- Cystitis6%
- Vertigo5%
- Edema peripheral5%
- Upper respiratory tract infection5%
- Sciatica5%
- Pneumonia4%
- Bone pain4%
- Anemia3%
- Angina pectoris3%
- Abdominal pain upper3%
- Myalgia3%
- Insomnia3%
- Rash3%
- Atrial fibrillation2%
- Flatulence2%
- Gastroesophageal reflux disease2%
- Asthenia2%
- Pharyngitis2%
- Herpes zoster2%
- Spinal osteoarthritis2%
- Pruritus2%
- Mortality2%
- Adverse events2%
Risks and risk factors
- Pain in the bones and muscles
- Problems in the jawbone
- Oral or dental surgery
- Cancer
- Poor oral hygiene
- Leg bone fractures
- Low calcium in the blood
- Low parathyroid hormone
- History of thyroid surgery
- Problems with calcium absorption
- Kidney injury
- Kidney disease
- Taking a water pill
- Dehydrated
- Elderly
- Leg bone fractures
- Taking steroids
- Hypersensitivity (allergic) reactions
- Low calcium blood levels
- Kidney problems
- Not taking calcium supplements
- Taking other medicines that can lower calcium blood levels
- History of hypoparathyroidism (low levels of parathyroid hormone)
- Infection
- Weak immune system
- Taking medicines that block your immune system (such as transplant medications or steroids)
- Problems in the jaw bone
- Oral or dental surgery
- Cancer diagnosis
- Taking steroids or chemotherapy
- Poor oral hygiene
- Pain in the bones and muscles