Compare Relafen vs. Acetaminophen with codeine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Relieves pain and inflammation.

Relafen (nabumetone) works well for relieving pain and inflammation, but may take up to a week to kick in.

Treats mild to moderate pain.

Acetaminophen with codeine (acetaminophen / codeine) is a good option to treat pain when over-the-counter medicines aren't enough, but don't take too much acetaminophen (Tylenol) since it can hurt your liver.

3.7/ 5 average rating with 581 reviewsforAcetaminophen with codeine
Upsides
  • Relafen (nabumetone) is good for relieving pain and inflammation from osteoarthritis and rheumatoid arthritis.
  • Usually taken only once a day, while other NSAIDS need to be taken a few times a day for the same effect.
  • Relafen (nabumetone) causes less stomach upset and overall side effects than other NSAIDs, like ibuprofen and naproxen.
  • Combination pain medicine with an opioid component (codeine) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relief in a single pill.
  • Provides quick relief for mild to moderate pain.
  • Good for as-needed pain and control.
  • Generally well tolerated, especially if taken with food to lower risk of stomach upset.
  • Lower rates of misuse compared to pure opioid medicines.
Downsides
  • Relafen (nabumetone) does not work as quickly as other NSAIDs.
  • Relafen (nabumetone), like other NSAIDS, is not safe for pregnant women and people who are age 60 or older.
  • Relafen (nabumetone) can cause serious complications including stomach bleeding and kidney problems if taken for a long period of time.
  • The safety and effectiveness of Relafen (nabumetone) for children are not known so they should not take it.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Many people get constipated taking Acetaminophen with codeine (acetaminophen / codeine).
  • All opioid containing medicines have the risk of addiction and withdrawal when used long-term.
  • Acetaminophen (Tylenol) has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful since many over-the-counter medicines also have acetaminophen.
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Dosage forms
  • Pill
  • Pill
  • Liquid
Price
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Reviews
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581 reviews so far
69%
saidit'sworth it
41%
saiditworked well
9%
saidit'sa big hassle

Have you used Acetaminophen with codeine (acetaminophen / codeine)?

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Side effects
3possible side effects
  • Diarrhea
    14%
  • Upset stomach
    13%
  • Stomach pain
    12%
See more detailed side effects
The Acetaminophen with codeine (acetaminophen / codeine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Heart attack and stroke
    • History of heart problems
    • Taking Relafen (nabumetone) for a long period of time
  • Stomach bleeding
    • History of stomach bleeding and/or ulcers
    • Age 60 or older
    • Taking aspirin, other NSAIDs, steroids, or blood thinners
    • Drinking alcoholic beverages
    • Smoking
    • Taking the medicine for a long period of time
    • People with poor general health
  • Severe allergic reaction
    • Asthma
    • Nasal polyps
    • Aspirin allergy
    • NSAID allergy
  • Kidney damage
    • Kidney disease
    • Heart failure
    • Liver disease
    • Taking certain high blood pressure medications
    • Age 60 or older
    • Taking the medicine for a long period of time
  • Harm to fetus
    • Pregnant women
    • Women who want to or can become pregnant
  • Heart-related complications
    • Recent heart surgery or heart attack
    • History of high blood pressure
    • History of heart failure
See more detailed risks and warnings
  • Liver failure and death
    • Alcohol use
    • Taking over-the-counter medicines with acetaminophen
    • History of liver disease
  • High risk to children
  • Use with other CNS depressants
    • Use with alcohol
    • Use with benzodiazepines
    • Use with other opiates
  • Severe allergic reaction
See more detailed risks and warnings