Compare Relafen vs. Lodine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Relieves pain and inflammation.

Relafen (nabumetone) works well for relieving pain and inflammation, but may take up to a week to kick in.

No information currently available
Upsides
  • Relafen (nabumetone) is good for relieving pain and inflammation from osteoarthritis and rheumatoid arthritis.
  • Usually taken only once a day, while other NSAIDS need to be taken a few times a day for the same effect.
  • Relafen (nabumetone) causes less stomach upset and overall side effects than other NSAIDs, like ibuprofen and naproxen.
No information currently available
Downsides
  • Relafen (nabumetone) does not work as quickly as other NSAIDs.
  • Relafen (nabumetone), like other NSAIDS, is not safe for pregnant women and people who are age 60 or older.
  • Relafen (nabumetone) can cause serious complications including stomach bleeding and kidney problems if taken for a long period of time.
  • The safety and effectiveness of Relafen (nabumetone) for children are not known so they should not take it.
No information currently available
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Used for
  • Juvenile rheumatoid arthritis Osteoarthritis Pain Rheumatoid arthritis
Dosage forms
  • Pill
  • Pill
  • Extended release
Price
Lowest price
$17.42
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Lowest price
$34.67
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Reviews
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Side effects
3possible side effects
  • Diarrhea
    14%
  • Upset stomach
    13%
  • Stomach pain
    12%
See more detailed side effects
The Lodine (Etodolac) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Heart attack and stroke
    • History of heart problems
    • Taking Relafen (nabumetone) for a long period of time
  • Stomach bleeding
    • History of stomach bleeding and/or ulcers
    • Age 60 or older
    • Taking aspirin, other NSAIDs, steroids, or blood thinners
    • Drinking alcoholic beverages
    • Smoking
    • Taking the medicine for a long period of time
    • People with poor general health
  • Severe allergic reaction
    • Asthma
    • Nasal polyps
    • Aspirin allergy
    • NSAID allergy
  • Kidney damage
    • Kidney disease
    • Heart failure
    • Liver disease
    • Taking certain high blood pressure medications
    • Age 60 or older
    • Taking the medicine for a long period of time
  • Harm to fetus
    • Pregnant women
    • Women who want to or can become pregnant
  • Heart-related complications
    • Recent heart surgery or heart attack
    • History of high blood pressure
    • History of heart failure
See more detailed risks and warnings
No information currently available
Learn more about Relafen (nabumetone)
Learn more about Lodine (Etodolac)