Compare Relistor vs. Colace

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Colace (docusate)

Treats opioid-induced constipation.

When laxatives aren't enough, Relistor (methylnaltrexone) can help treat constipation caused by opioids without affecting opioid pain relief.

Softens your stools.

Colace (docusate) softens the stool, but may not stimulate a bowel movement as quickly as a laxative.

3.6/ 5 average rating with 125 reviewsforColace
  • Relistor (methylnaltrexone) relieves your constipation with an easy to take once daily dose.
  • It’s an effective option when other constipation medicines don’t work for you.
  • Fast relief allows you to predict when your bowel movement will occur, allowing you to plan your day.
  • You might be eligible for a savings card that lowers your copay. Talk to your doctor or pharmacist.
  • Safer than laxatives.
  • Available over-the-counter.
  • Safe to use in children as young as 2 years old.
  • Relistor (methylnaltrexone) is generally reserved for more severe constipation. Your doctor will have you try other constipation medications first.
  • It’s more expensive than other medicines used to treat constipation.
  • Let your doctor know what other medications you are currently taking as certain drugs can interact with Relistor (methylnaltrexone).
  • May take up to 5 days for the full effects to kick in.
  • Intended to be used only as a short-term solution for occasional constipation. Other options such as fiber supplements may be more useful for maintaining regular bowel movements.
Used for
  • Opioid-induced constipation
Dosage forms
  • Pill
  • Injection
  • Pill
  • Enema
  • Liquid
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125 reviews so far
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Side effects
5possible side effects
  • Stomach pain
  • Passing gas
  • Nausea
  • Dizziness
  • Diarrhea
See more detailed side effects
The Colace (docusate) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Hole in the bowel
    • History of bowel or stomach problems
  • Diarrhea
  • Opioid withdrawal
  • Bad liver function
    • History of liver problems
  • Bad kidney function
    • History of kidney problems
See more detailed risks and warnings
  • Complete or partial blockage of intestines
See more detailed risks and warnings