Compare Relistor vs. Symproic

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Symproic (naldemedine)

Prescription only
Treats opioid-induced constipation.

When laxatives aren't enough, Relistor (methylnaltrexone) can help treat constipation caused by opioids without affecting opioid pain relief.

Relieves constipation caused by opiate pain medications.

Symproic (naldemedine) quickly relieves constipation caused by opioids without affecting pain relief, but it can be expensive.

  • Relistor (methylnaltrexone) relieves your constipation with an easy to take once daily dose.
  • It’s an effective option when other constipation medicines don’t work for you.
  • Fast relief allows you to predict when your bowel movement will occur, allowing you to plan your day.
  • You might be eligible for a savings card that lowers your copay. Talk to your doctor or pharmacist.
  • Symproic (naldemedine) is a good option if traditional laxatives have not worked for you.
  • You only have to take Symproic (naldemedine) once a day.
  • Symproic (naldemedine) doesn't affect how opioids treat pain.
  • It works much faster than most other laxatives.
  • It does not have to be dose adjusted if you have kidney problems.
  • Relistor (methylnaltrexone) is generally reserved for more severe constipation. Your doctor will have you try other constipation medications first.
  • It’s more expensive than other medicines used to treat constipation.
  • Let your doctor know what other medications you are currently taking as certain drugs can interact with Relistor (methylnaltrexone).
  • Symproic (naldemedine) is not available as a cheaper generic form.
  • It is more expensive than traditional axatives.
  • This medication is not a good option if you have severe liver problems.
Used for
  • Opioid-induced constipation
  • Opioid-induced constipation
Dosage forms
  • Pill
  • Injection
  • Pill
Lowest price
Find instant savings near you
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Learn more
Not enough review data.Leave a review
Not enough review data.Leave a review
Side effects
5possible side effects
  • Stomach pain
  • Passing gas
  • Nausea
  • Dizziness
  • Diarrhea
See more detailed side effects
4possible side effects
  • Stomach pain
  • Diarrhea
  • Nausea
  • Stomach flu
See more detailed side effects
Risks and risk factors
  • Hole in the bowel
    • History of bowel or stomach problems
  • Diarrhea
  • Opioid withdrawal
  • Bad liver function
    • History of liver problems
  • Bad kidney function
    • History of kidney problems
See more detailed risks and warnings
  • Opioid withdrawal and reduced pain relief
  • Stomach or intestinal holes
    • Crohns disease
    • Peptic ulcer disease
    • Diverticular disease
    • Stomach malignancies
    • Ogilvie’s syndrome
See more detailed risks and warnings