Compare Remeron vs. Pristiq

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Remeron (mirtazapine)

Prescription only

Pristiq (desvenlafaxine)

Prescription only
Improves mood.

Remeron (mirtazapine) improves your mood and helps you sleep better, but can cause more weight gain than any other antidepressant.

3.3/ 5 average rating with 152 reviewsforRemeron
Improves mood.

Pristiq (desvenlafaxine) is an effective medicine for treating depression, but it is more expensive than many other medicines that work just like it.

3.5/ 5 average rating with 196 reviewsforPristiq
Upsides
  • Effective at relieving some depression symptoms.
  • Starts to work more quickly than most antidepressants.
  • Can help you fall asleep if you have trouble sleeping.
  • Can also help relieve anxiety.
  • Good option if you are underweight or frail, because it can help you gain weight.
  • Available as a generic.
  • You only need to take Pristiq (desvenlafaxine) once a day.
  • May be taken with or without food.
  • Less sedating than other anti-depressants.
Downsides
  • Makes you more tired than other antidepressants.
  • More likely to cause minor weight gain (1-5 pounds) and raise cholesterol than any other antidepressant.
  • Like most anti-depressants, full effect on mood takes up to 12 weeks.
  • Can increase the risk of suicidal thoughts and/or behavior in yound adults 24 years and younger.
  • Can affect your sex drive and ability to get an erection.
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Used for
Dosage forms
  • Pill
  • Dissolving tablet
  • Extended-release pill
Price
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Reviews
152 reviews so far
45%
saidit'sworth it
39%
saiditworked well
26%
saidit'sa big hassle

Have you used Remeron (mirtazapine)?

Leave a review
196 reviews so far
53%
saidit'sworth it
49%
saiditworked well
23%
saidit'sa big hassle

Have you used Pristiq (desvenlafaxine)?

Leave a review
Side effects
17possible side effects
  • Sleepiness
    54%
  • Dry mouth
    25%
  • Increased appetite  
    17%
  • Increased appetite
    17%
  • Constipation
    13%
  • Weight gain
    12%
  • Lack of energy
    8%
  • Dizziness
    7%
  • Flu syndrome
    5%
  • Abnormal dreams
    4%
  • Abnormal thinking
    3%
  • Back pain
    2%
  • Swelling in limbs
    2%
  • Muscle pain
    2%
  • Tremor
    2%
  • Confusion
    2%
  • Urinary frequency
    2%
See more detailed side effects
17possible side effects
  • Nausea
    22%
  • Dizziness
    13%
  • Dry mouth
    11%
  • Excessive sweating
    10%
  • Constipation
    9%
  • Inability to sleep
    9%
  • Tiredness
    7%
  • Decreased appetite
    5%
  • Drowsiness
    4%
  • Vomiting
    3%
  • Anxiety
    3%
  • Blurry vision
    3%
  • Tremor
    2%
  • Abnormal dreams
    2%
  • Dilated pupils
    2%
  • Vertigo
    2%
  • Ringing in ears
    2%
See more detailed side effects
Risks and risk factors
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Serotonin syndrome
    • Using other medications that affect serotonin
  • Heart problems
    • History of heart problems
    • History of liver problems
    • Higher dose
  • Driving impairment
    • Alcohol
    • Taking other medicines that make you less alert
  • Weight gain
  • Blood disorders
See more detailed risks and warnings
  • Suicidal thoughts or behavior
    • Age 24 or younger
  • Serotonin syndrome
    • Taking other medicines that also increase serotonin activity: Antidepressants (SSRIs, SNRIs, TCAs)
    • lithium
    • tramadol
    • Imitrex
    • Remeron
    • Lexapro
    • Dilaudid
  • Increased blood pressure
    • People with a history of high blood pressure or other heart conditions
  • Increased bleeding risk
    • Taking NSAIDS, blood thinners, or aspirin
  • Low sodium levels in blood
    • Older people
    • Taking diuretics
  • Stopping Pristiq (desvenlafaxine) too quickly
    • Taking the medicine for a long time
    • Stopping Pristiq (desvenlafaxine) too quickly
See more detailed risks and warnings