Compare Remicade vs. Simponi

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Remicade (infliximab)

Prescription only

Simponi (golimumab)

Prescription only
Calms down your immune system.

Remicade (infliximab) is an effective treatment for many autoimmune diseases, but you can have serious side effects.

4.0/ 5 average rating with 55 reviewsforRemicade
Calms down the immune system.

Simponi (golimumab) effectively calms down your immune system, but it is given as a shot and puts you at risk of serious infections like tuberculosis or hepatitis B.

Upsides
  • People taking Remicade (infliximab) for ulcerative colitis, Crohn's disease, rheumatoid arthritis and other autoimmune conditions had more clinical response, clinical remission and symptom improvement compared to people who did not take Remicade (infliximab).
  • People who were also taking steroids for treatment were able to discontinue steroid use while taking Remicade (infliximab).
  • Remicade (infliximab) has almost two decades of clinical trial data and real-life experience with many people who have used it.
  • After the initial dosing, you only need to take Remicade (infliximab) every 6-8 weeks, depending on your condition.
  • Compared to other medications used to treat autoimmune conditions, Remicade (infliximab) has not been associated with as many harmful effects during pregnancy and breastfeeding.
  • Simponi (golimumab) is only injected once a month.
  • Simponi (golimumab) comes in a prefilled syringe or autoinjector. You won't need to measure out the medication.
  • While taking Simponi (golimumab), you may continue to use other drugs prescribed by your doctor that help treat your condition, such as NSAIDS (like ibuprofen) and steroids.
Downsides
  • You have to receive this medication at your doctor's office or clinic. You might need to be tested regularly for tuberculosis.
  • Remicade (infliximab) lowers your ability to fight infection and can cause serious illness. The risk is greater if you take other drugs that lower your immune system, or have a history of diabetes or tuberculosis.
  • Remicade (infliximab) can in some cases worsen symptoms of heart failure or neurologic conditions. People 65 years and older may have more side effects from this medication.
  • In rare cases, Remicade (infliximab) has been associated with cancers in children and adolescents.
  • No generic available, so it can be costly.
  • Like other immunosuppressive drugs, Simponi (golimumab) can awaken (reactivate) infections.
  • Simponi (golimumab) can increase the risk of lymphoma, leukemia, and other cancers.
  • Not the best choice if you have a history of heart failure or nervous system problems like multiple sclerosis.
  • You'll need to have regular blood tests before and during treatment to make sure you don't have any problems taking Simponi (golimumab).
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Used for
Dosage forms
  • Injection
  • Injection
Price
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$11502.32
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Reviews
55 reviews so far
76%
saidit'sworth it
62%
saiditworked well
15%
saidit'sa big hassle

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Side effects
7possible side effects
  • Anemia
    11%
  • Low white blood cell count
    9%
  • Flushing
    9%
  • Viral infection
    8%
  • Bone fracture
    7%
  • Bacterial infection
    6%
  • Allergic reaction
    6%
See more detailed side effects
11possible side effects
  • Common cold
    16%
  • Injection site reaction
    6%
  • Viral infections (such as influenza and herpes)
    5%
  • Increased liver function test (ALT)
    4%
  • Increased liver function test (AST)
    3%
  • High blood pressure
    3%
  • Bronchitis
    2%
  • Superficial fungal infections
    2%
  • Sinusitis
    2%
  • Dizziness
    2%
  • Tingling sensation
    2%
See more detailed side effects
Risks and risk factors
  • Serious infections
    • Taking other immunosuppressant drugs
    • Age 65 or older
    • Comorbidities
  • Cancer
    • Taking other immunosuppressant drugs
    • History of malignancy
  • Heart failure
    • History of heart failure
    • Receiving higher doses
  • Nervous system effects
    • History of nerve problems
  • Lower blood cell counts
    • Ongoing or history of blood problems
  • Liver injury
See more detailed risks and warnings
  • High risk of infections with TNF inhibitors
    • Taking other immunosuppressant drugs
    • Age 65 or older
    • Active, chronic, or recurrent infection
  • Cancer
    • Taking other immunosuppressant drugs
    • History of malignancy
    • People with rheumatoid arthritis
    • Adolescent age
  • Nervous system effects
    • History of neurologic condition
  • History of heart failure
    • History of heart failure
  • Lower number of blood cells
See more detailed risks and warnings