Compare Renova vs. Differin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Renova (Tretinoin)

Prescription only

Differin (adapalene)

Prescription or OTC
Treats acne and sun damage.

Renova (Tretinoin) isn't a cure for fine lines and wrinkles, but it's clinically proven to improve them.

3.1/ 5 average rating with 58 reviewsforRenova
Treats acne.

Differin (adapalene) is commonly used for treating acne, but, it can cause skin irritation.

Upsides
  • You only need to apply it once a day, usually in the evening.
  • Most people who reported having skin irritation said that it was mild.
  • Part of a complete program to help you take better care of your skin.
  • Differin (adapalene) is a good option for the treatment of acne.
  • It is available as a cheaper, generic medication.
  • It only has to be applied to the skin once a day at bedtime.
  • The 0.1% gel formulation is available over the counter, without a prescription.
  • Differin (adapalene) is generally well tolerated, with few side effects.
Downsides
  • It may take up to 6 months to see the full benefit for facial wrinkles.
  • Not a good choice for women who want to become or are pregnant
  • Can change the color and texture of your skin if used long-term.
  • You need to be careful about avoiding any sunlight or artificial tanning while using it.
  • It doesn't work for deep wrinkles.
  • Your skin may look worse before it starts looking better.
  • Differin (adapalene) can take up to 8 to 12 week to start working.
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Used for
Dosage forms
  • Cream, gel, or ointment
  • Cream
  • Gel
  • Lotion
Price
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Reviews
58 reviews so far
41%
saidit'sworth it
28%
saiditworked well
28%
saidit'sa big hassle

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Side effects
4possible side effects
  • Mild skin reactions
    100%
  • Severe local irritation
    7%
  • Any side effect
    4%
  • Skin hypo- or hyperpigmentation
    2%
See more detailed side effects
5possible side effects
  • Skin dryness
    42%
  • Skin redness
    38%
  • Skin scaling
    35%
  • Persistent burning and stinging
    24%
  • Persistent itching
    21%
See more detailed side effects
Risks and risk factors
  • Skin irritation
    • Using other medicines or products that irritate the skin
    • Eczema
    • Extreme temperatures (hot or cold)
  • Sun sensitivity
  • Allergic reactions
    • Allergy to fish or fish products
  • Harm to fetus
See more detailed risks and warnings
  • Local skin reactions
    • Soaps and cleansers with skin-drying effects
    • Products with high concentraions of alcohol, astringents, spices, or limes.
  • UV and sunlight exposure
  • Severe allergic reaction
See more detailed risks and warnings