Compare Reyataz vs. Crixivan

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Reyataz (atazanavir)

Prescription only

Crixivan (indinavir)

Prescription only
Treats HIV infection.

Reyataz (atazanavir) works well with other HIV medicines to treat HIV, but it's not a first-line choice due to its side effects, and you must take it with food.

Treats HIV infection.

Crixivan (indinavir) is a good alternative drug used with other medications to treat HIV, but is not a first-choice treatment because of its side effects and many drug interactions.

Upsides
  • If first-line choices for HIV medicines are not an option, Reyataz (atazanavir) is a good alternative to consider.
  • Conveniently taken once daily.
  • Available in powder form for mixing if pills are hard to swallow.
  • A safer choice than Prezista (darunavir) or Prezcobix (darunavir/cobicistat) for people with heart problems.
  • Good choice for people with kidney problems.
  • Can be effective at treating HIV infection if other medicines have not worked.
Downsides
  • Reyataz (atazanavir) can interact with many other medicines. Talk to your doctor or pharmacist before starting or stopping medicines.
  • Not a good choice for people with uncontrolled diabetes, liver problems, or history of gallstones or kidney stones.
  • Needs to be taken with other HIV medicines.
  • Reyataz (atazanavir) powder contains phenylalanine, which is harmful to people who can't digest phenylalanine (i.e., phenylketonuria).
  • Crixivan (indinavir) interacts with many other drugs. Talk to your doctor or pharmacist before starting any new medications.
  • Crixivan (indinavir) can cause kidney stones so it's important to stay hydrated.
  • Crixivan (indinavir) might cause yellowing of the skin or eyes.
  • Crixivan (indinavir) can cause high cholesterol, triglyceride, and blood sugar levels.
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Used for
Dosage forms
  • Pill
  • Powder
  • Pill
Price
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Reviews
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Side effects
13possible side effects
  • Nausea
    14%
  • Yellowing of skin and eyes
    9%
  • Rash
    7%
  • Headache
    6%
  • Vomiting
    4%
  • Stomach pain
    4%
  • Burning or tingling in hands, arms, legs, or feet
    4%
  • Muscle pain
    4%
  • Trouble sleeping
    3%
  • Diarrhea
    3%
  • Dizziness
    2%
  • Fever
    2%
  • Depression
    2%
See more detailed side effects
21possible side effects
  • Abdominal pain
    17%
  • Kidney stones
    12%
  • Nausea
    12%
  • Elevated serum bilirubin
    12%
  • Vomiting
    8%
  • Back pain
    8%
  • Headache
    5%
  • Itching
    4%
  • Diarrhea
    3%
  • Acid regurgitation
    3%
  • Anorexia
    3%
  • Dizziness
    3%
  • Metallic taste
    3%
  • Weakness/fatigue
    2%
  • Fever
    2%
  • Discomfort
    2%
  • Increased appetite
    2%
  • Indigestion
    2%
  • Yellowing of skin and eyes
    2%
  • Sleepiness
    2%
  • Cough
    2%
See more detailed side effects
Risks and risk factors
  • Changes in heartbeat
    • History of heartbeat problems
    • Taking other medicines that can affect your heartbeat
  • High bilirubin levels
  • New or worsening diabetes
    • Diabetes
  • Immune reconstitution syndrome
    • HIV
    • Exposure to other infections
    • Start of a new HIV medicine
    • Change in HIV therapy
  • Liver damage
    • History of liver damage
    • Hepatitis B or C
  • Severe skin reactions
See more detailed risks and warnings
  • New onset or worsened diabetes
    • Use of protease inhibitors
    • Diabetes
  • Hemolytic anemia
  • Liver damage
    • History of liver damage
  • Drug interactions
  • Kidney stones
    • Children
    • Dehydration
  • Fat redistribution
    • HIV treatment
See more detailed risks and warnings